Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely due to inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells (PSCs) and consequent development of dense stroma are prominent features accounting for this aggressive biology(1,2). The recipro...

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Detalles Bibliográficos
Autores principales: Shi, Yu, Gao, Weina, Lytle, Nikki K., Huang, Peiwu, Yuan, Xiao, Dann, Amanda M., Ridinger-Saison, Maya, DelGiorno, Kathleen E., Antal, Corina E., Liang, Gaoyang, Atkins, Annette R., Erikson, Galina, Sun, Huaiyu, Meisenhelder, Jill, Terenziani, Elena, Woo, Gyunghwi, Fang, Linjing, Santisakultarm, Thom P., Manor, Uri, Xu, Ruilian, Becerra, Carlos R., Borazanci, Erkut, Von Hoff, Daniel D., Grandgenett, Paul M., Hollingsworth, Michael A., Leblanc, Mathias, Umetsu, Sarah E., Collisson, Eric A., Scadeng, Miriam, Lowy, Andrew M., Donahue, Timothy R., Reya, Tannishtha, Downes, Michael, Evans, Ronald M., Wahl, Geoffrey M., Pawson, Tony, Tian, Ruijun, Hunter, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565370/
https://www.ncbi.nlm.nih.gov/pubmed/30996350
http://dx.doi.org/10.1038/s41586-019-1130-6

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