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Periprosthetic Joint Infections as a Consequence of Bacteremia

BACKGROUND: The risk for developing a periprosthetic joint infection (PJI) during bacteremia is unclear, except for Staphylococcus aureus bacteremia. The aim of this study was to examine the risk for developing a PJI during bacteremia and to identify possible risk factors leading to it. METHODS: Pat...

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Autores principales: Honkanen, Meeri, Jämsen, Esa, Karppelin, Matti, Huttunen, Reetta, Eskelinen, Antti, Syrjänen, Jaana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565379/
https://www.ncbi.nlm.nih.gov/pubmed/31214625
http://dx.doi.org/10.1093/ofid/ofz218
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author Honkanen, Meeri
Jämsen, Esa
Karppelin, Matti
Huttunen, Reetta
Eskelinen, Antti
Syrjänen, Jaana
author_facet Honkanen, Meeri
Jämsen, Esa
Karppelin, Matti
Huttunen, Reetta
Eskelinen, Antti
Syrjänen, Jaana
author_sort Honkanen, Meeri
collection PubMed
description BACKGROUND: The risk for developing a periprosthetic joint infection (PJI) during bacteremia is unclear, except for Staphylococcus aureus bacteremia. The aim of this study was to examine the risk for developing a PJI during bacteremia and to identify possible risk factors leading to it. METHODS: Patients with a primary knee or hip joint replacement performed in a tertiary care hospital between September 2002 and December 2013 were identified (n = 14 378) and followed up until December 2014. Positive blood culture results during the study period and PJIs were recorded. PJIs associated with an episode of bacteremia were identified and confirmed from patient records. Potential risk factors for PJI among those with bacteremia were examined using univariate logistic regression. RESULTS: A total of 542 (3.8%) patients had at least 1 episode of bacteremia. Seven percent (47/643) of the bacteremias resulted in a PJI. Development of a PJI was most common for Staphylococcus aureus (21% of bacteremias led to a PJI) and beta-hemolytic streptococci (21%), whereas it was rare for gram-negative bacteria (1.3%). Having ≥2 bacteremias during the study period increased the risk for developing a PJI (odds ratio, 2.29; 95% confidence interval, 1.17–4.50). The risk for developing a PJI was highest for bacteremias occurring within a year of previous surgery. Chronic comorbidities did not affect the risk for PJI during bacteremia. CONCLUSIONS: The development of a PJI during bacteremia depends on the pathogen causing the bacteremia and the timing of bacteremia with respect to previous joint replacement surgery. However, significant patient-related risk factors for PJI during bacteremia could not be found.
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spelling pubmed-65653792019-06-18 Periprosthetic Joint Infections as a Consequence of Bacteremia Honkanen, Meeri Jämsen, Esa Karppelin, Matti Huttunen, Reetta Eskelinen, Antti Syrjänen, Jaana Open Forum Infect Dis Major Article BACKGROUND: The risk for developing a periprosthetic joint infection (PJI) during bacteremia is unclear, except for Staphylococcus aureus bacteremia. The aim of this study was to examine the risk for developing a PJI during bacteremia and to identify possible risk factors leading to it. METHODS: Patients with a primary knee or hip joint replacement performed in a tertiary care hospital between September 2002 and December 2013 were identified (n = 14 378) and followed up until December 2014. Positive blood culture results during the study period and PJIs were recorded. PJIs associated with an episode of bacteremia were identified and confirmed from patient records. Potential risk factors for PJI among those with bacteremia were examined using univariate logistic regression. RESULTS: A total of 542 (3.8%) patients had at least 1 episode of bacteremia. Seven percent (47/643) of the bacteremias resulted in a PJI. Development of a PJI was most common for Staphylococcus aureus (21% of bacteremias led to a PJI) and beta-hemolytic streptococci (21%), whereas it was rare for gram-negative bacteria (1.3%). Having ≥2 bacteremias during the study period increased the risk for developing a PJI (odds ratio, 2.29; 95% confidence interval, 1.17–4.50). The risk for developing a PJI was highest for bacteremias occurring within a year of previous surgery. Chronic comorbidities did not affect the risk for PJI during bacteremia. CONCLUSIONS: The development of a PJI during bacteremia depends on the pathogen causing the bacteremia and the timing of bacteremia with respect to previous joint replacement surgery. However, significant patient-related risk factors for PJI during bacteremia could not be found. Oxford University Press 2019-05-07 /pmc/articles/PMC6565379/ /pubmed/31214625 http://dx.doi.org/10.1093/ofid/ofz218 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Article
Honkanen, Meeri
Jämsen, Esa
Karppelin, Matti
Huttunen, Reetta
Eskelinen, Antti
Syrjänen, Jaana
Periprosthetic Joint Infections as a Consequence of Bacteremia
title Periprosthetic Joint Infections as a Consequence of Bacteremia
title_full Periprosthetic Joint Infections as a Consequence of Bacteremia
title_fullStr Periprosthetic Joint Infections as a Consequence of Bacteremia
title_full_unstemmed Periprosthetic Joint Infections as a Consequence of Bacteremia
title_short Periprosthetic Joint Infections as a Consequence of Bacteremia
title_sort periprosthetic joint infections as a consequence of bacteremia
topic Major Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565379/
https://www.ncbi.nlm.nih.gov/pubmed/31214625
http://dx.doi.org/10.1093/ofid/ofz218
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