Cargando…

The association of nucleotide‐binding oligomerization domain 2 gene polymorphisms with the risk of asthma in the Chinese Han population

BACKGROUND: Genetic background is one of the important risk factors for development of asthma. The nucleotide‐binding oligomerization domain 2 (NOD2) has been involved in the pathogenesis of asthma. The purpose of this study was to explore the relationship between NOD2 gene polymorphisms and asthma...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Xulong, Xu, Qiaolan, Zhou, Chenrong, Zhou, Li, Dai, Weihua, Ji, Guanchi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565575/
https://www.ncbi.nlm.nih.gov/pubmed/30950247
http://dx.doi.org/10.1002/mgg3.675
_version_ 1783426673645977600
author Cai, Xulong
Xu, Qiaolan
Zhou, Chenrong
Zhou, Li
Dai, Weihua
Ji, Guanchi
author_facet Cai, Xulong
Xu, Qiaolan
Zhou, Chenrong
Zhou, Li
Dai, Weihua
Ji, Guanchi
author_sort Cai, Xulong
collection PubMed
description BACKGROUND: Genetic background is one of the important risk factors for development of asthma. The nucleotide‐binding oligomerization domain 2 (NOD2) has been involved in the pathogenesis of asthma. The purpose of this study was to explore the relationship between NOD2 gene polymorphisms and asthma susceptibility in the Chinese Han population. METHODS: Children with asthma (n = 309) and Healthy children (n = 163) were recruited from Yancheng Third People's Hospital, Yancheng, China, between January 2016 and December 2017. The NOD2 gene polymorphisms were measured by the Snapshot SNP genotyping assays. Genotyping was performed for 4 tag SNPs of NOD2. Serum IFN‐β levels were measured by ELISA. RESULTS: The serum IFN‐β levels were significantly lower in Asthmatic children than those in the controls (p < 0.001). Low levels of IFN‐β may be related to the susceptibility to severe asthma. The rs3135499 C allele was associated with a significantly increased risk of asthma as compared with the rs3135499 A allele. CONCLUSION: The rs3135499 polymorphism of NOD2 gene and IFN‐β may play a role in the pathogenesis of asthma.
format Online
Article
Text
id pubmed-6565575
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-65655752019-06-20 The association of nucleotide‐binding oligomerization domain 2 gene polymorphisms with the risk of asthma in the Chinese Han population Cai, Xulong Xu, Qiaolan Zhou, Chenrong Zhou, Li Dai, Weihua Ji, Guanchi Mol Genet Genomic Med Original Articles BACKGROUND: Genetic background is one of the important risk factors for development of asthma. The nucleotide‐binding oligomerization domain 2 (NOD2) has been involved in the pathogenesis of asthma. The purpose of this study was to explore the relationship between NOD2 gene polymorphisms and asthma susceptibility in the Chinese Han population. METHODS: Children with asthma (n = 309) and Healthy children (n = 163) were recruited from Yancheng Third People's Hospital, Yancheng, China, between January 2016 and December 2017. The NOD2 gene polymorphisms were measured by the Snapshot SNP genotyping assays. Genotyping was performed for 4 tag SNPs of NOD2. Serum IFN‐β levels were measured by ELISA. RESULTS: The serum IFN‐β levels were significantly lower in Asthmatic children than those in the controls (p < 0.001). Low levels of IFN‐β may be related to the susceptibility to severe asthma. The rs3135499 C allele was associated with a significantly increased risk of asthma as compared with the rs3135499 A allele. CONCLUSION: The rs3135499 polymorphism of NOD2 gene and IFN‐β may play a role in the pathogenesis of asthma. John Wiley and Sons Inc. 2019-04-04 /pmc/articles/PMC6565575/ /pubmed/30950247 http://dx.doi.org/10.1002/mgg3.675 Text en © 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Cai, Xulong
Xu, Qiaolan
Zhou, Chenrong
Zhou, Li
Dai, Weihua
Ji, Guanchi
The association of nucleotide‐binding oligomerization domain 2 gene polymorphisms with the risk of asthma in the Chinese Han population
title The association of nucleotide‐binding oligomerization domain 2 gene polymorphisms with the risk of asthma in the Chinese Han population
title_full The association of nucleotide‐binding oligomerization domain 2 gene polymorphisms with the risk of asthma in the Chinese Han population
title_fullStr The association of nucleotide‐binding oligomerization domain 2 gene polymorphisms with the risk of asthma in the Chinese Han population
title_full_unstemmed The association of nucleotide‐binding oligomerization domain 2 gene polymorphisms with the risk of asthma in the Chinese Han population
title_short The association of nucleotide‐binding oligomerization domain 2 gene polymorphisms with the risk of asthma in the Chinese Han population
title_sort association of nucleotide‐binding oligomerization domain 2 gene polymorphisms with the risk of asthma in the chinese han population
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565575/
https://www.ncbi.nlm.nih.gov/pubmed/30950247
http://dx.doi.org/10.1002/mgg3.675
work_keys_str_mv AT caixulong theassociationofnucleotidebindingoligomerizationdomain2genepolymorphismswiththeriskofasthmainthechinesehanpopulation
AT xuqiaolan theassociationofnucleotidebindingoligomerizationdomain2genepolymorphismswiththeriskofasthmainthechinesehanpopulation
AT zhouchenrong theassociationofnucleotidebindingoligomerizationdomain2genepolymorphismswiththeriskofasthmainthechinesehanpopulation
AT zhouli theassociationofnucleotidebindingoligomerizationdomain2genepolymorphismswiththeriskofasthmainthechinesehanpopulation
AT daiweihua theassociationofnucleotidebindingoligomerizationdomain2genepolymorphismswiththeriskofasthmainthechinesehanpopulation
AT jiguanchi theassociationofnucleotidebindingoligomerizationdomain2genepolymorphismswiththeriskofasthmainthechinesehanpopulation
AT caixulong associationofnucleotidebindingoligomerizationdomain2genepolymorphismswiththeriskofasthmainthechinesehanpopulation
AT xuqiaolan associationofnucleotidebindingoligomerizationdomain2genepolymorphismswiththeriskofasthmainthechinesehanpopulation
AT zhouchenrong associationofnucleotidebindingoligomerizationdomain2genepolymorphismswiththeriskofasthmainthechinesehanpopulation
AT zhouli associationofnucleotidebindingoligomerizationdomain2genepolymorphismswiththeriskofasthmainthechinesehanpopulation
AT daiweihua associationofnucleotidebindingoligomerizationdomain2genepolymorphismswiththeriskofasthmainthechinesehanpopulation
AT jiguanchi associationofnucleotidebindingoligomerizationdomain2genepolymorphismswiththeriskofasthmainthechinesehanpopulation