Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors

Primary microcephaly is caused by mutations in genes encoding centrosomal proteins including WDR62 and KIF2A. However, mechanisms underlying human microcephaly remain elusive. By creating mutant mice and human cerebral organoids, here we found that WDR62 deletion resulted in a reduction in the size...

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Detalles Bibliográficos
Autores principales: Zhang, Wei, Yang, Si-Lu, Yang, Mei, Herrlinger, Stephanie, Shao, Qiang, Collar, John L., Fierro, Edgar, Shi, Yanhong, Liu, Aimin, Lu, Hui, Herring, Bruce E., Guo, Ming-Lei, Buch, Shilpa, Zhao, Zhen, Xu, Jian, Lu, Zhipeng, Chen, Jian-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565620/
https://www.ncbi.nlm.nih.gov/pubmed/31197141
http://dx.doi.org/10.1038/s41467-019-10497-2

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