Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we describe an in vitro microfluidic organ-on-a-chip BBB model lined by induced pluripotent stem cell-derived human brain microvascul...

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Detalles Bibliográficos
Autores principales: Park, Tae-Eun, Mustafaoglu, Nur, Herland, Anna, Hasselkus, Ryan, Mannix, Robert, FitzGerald, Edward A., Prantil-Baun, Rachelle, Watters, Alexander, Henry, Olivier, Benz, Maximilian, Sanchez, Henry, McCrea, Heather J., Goumnerova, Liliana Christova, Song, Hannah W., Palecek, Sean P., Shusta, Eric, Ingber, Donald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565686/
https://www.ncbi.nlm.nih.gov/pubmed/31197168
http://dx.doi.org/10.1038/s41467-019-10588-0

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