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Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection

During thymic negative selection, autoreactive thymocytes carrying T cell receptor (TCR) with overtly strong affinity to self-MHC/self-peptide are removed by Bim-dependent apoptosis, but how Bim is specifically regulated to link TCR activation and apoptosis induction is unclear. Here we identify a m...

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Detalles Bibliográficos
Autores principales:	Hojo, Miki Arai, Masuda, Kyoko, Hojo, Hiroaki, Nagahata, Yosuke, Yasuda, Keiko, Ohara, Daiya, Takeuchi, Yusuke, Hirota, Keiji, Suzuki, Yutaka, Kawamoto, Hiroshi, Kawaoka, Shinpei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565714/ https://www.ncbi.nlm.nih.gov/pubmed/31197149 http://dx.doi.org/10.1038/s41467-019-10525-1

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