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KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

Inhibiting the RAS oncogenic protein has largely been through targeting the switch regions that interact with signalling effector proteins. Here, we report designed ankyrin repeat proteins (DARPins) macromolecules that specifically inhibit the KRAS isoform by binding to an allosteric site encompassi...

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Detalles Bibliográficos
Autores principales:	Bery, Nicolas, Legg, Sandrine, Debreczeni, Judit, Breed, Jason, Embrey, Kevin, Stubbs, Christopher, Kolasinska-Zwierz, Paulina, Barrett, Nathalie, Marwood, Rose, Watson, Jo, Tart, Jon, Overman, Ross, Miller, Ami, Phillips, Christopher, Minter, Ralph, Rabbitts, Terence H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565726/ https://www.ncbi.nlm.nih.gov/pubmed/31197133 http://dx.doi.org/10.1038/s41467-019-10419-2

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