High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs

Organotypic culture systems from disease-specific induced pluripotent stem cells (iPSCs) exhibit obvious advantages compared with immortalized cell lines and primary cell cultures, but implementation of iPSC-based high-throughput (HT) assays is still technically challenging. Here, we demonstrate the...

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Detalles Bibliográficos
Autores principales: Merkert, Sylvia, Schubert, Madline, Olmer, Ruth, Engels, Lena, Radetzki, Silke, Veltman, Mieke, Scholte, Bob J., Zöllner, Janina, Pedemonte, Nicoletta, Galietta, Luis J.V., von Kries, Jens P., Martin, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565754/
https://www.ncbi.nlm.nih.gov/pubmed/31080112
http://dx.doi.org/10.1016/j.stemcr.2019.04.014

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