Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis

Zygotic genome activation (ZGA) begins after fertilization and is essential for establishing pluripotency and genome stability. However, it is unclear how ZGA genes prevent mitotic errors. Here we show that knockout of the ZGA gene Zscan5b, which encodes a SCAN domain with C2H2 zinc fingers, causes...

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Detalles Bibliográficos
Autores principales: Ogawa, Seiji, Yamada, Mitsutoshi, Nakamura, Akihiro, Sugawara, Tohru, Nakamura, Akari, Miyajima, Shoko, Harada, Yuichirou, Ooka, Reina, Okawa, Ryuichiro, Miyauchi, Jun, Tsumura, Hideki, Yoshimura, Yasunori, Miyado, Kenji, Akutsu, Hidenori, Tanaka, Mamoru, Umezawa, Akihiro, Hamatani, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565874/
https://www.ncbi.nlm.nih.gov/pubmed/31155506
http://dx.doi.org/10.1016/j.stemcr.2019.05.002

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