The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance

The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell proliferation, differentiation, cell survival, senescence, DNA damage repair and cell cycle control. The development of resistan...

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Detalles Bibliográficos
Autores principales: Yao, Shang, Fan, Lavender Yuen-Nam, Lam, Eric Wing-Fai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565931/
https://www.ncbi.nlm.nih.gov/pubmed/29180117
http://dx.doi.org/10.1016/j.semcancer.2017.11.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565931/
https://www.ncbi.nlm.nih.gov/pubmed/29180117
http://dx.doi.org/10.1016/j.semcancer.2017.11.018

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