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The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance
The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell proliferation, differentiation, cell survival, senescence, DNA damage repair and cell cycle control. The development of resistan...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Academic Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565931/ https://www.ncbi.nlm.nih.gov/pubmed/29180117 http://dx.doi.org/10.1016/j.semcancer.2017.11.018 |