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Mitochondrial integrity in neurodegeneration
The mitochondrion is a unique organelle with a diverse range of functions. Mitochondrial dysfunction is a key pathological process in several neurodegenerative diseases. Mitochondria are mostly important for energy production; however, they also have roles in Ca(2+) homeostasis, ROS production, and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566061/ https://www.ncbi.nlm.nih.gov/pubmed/30746905 http://dx.doi.org/10.1111/cns.13105 |
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author | Cowan, Katrina Anichtchik, Oleg Luo, Shouqing |
author_facet | Cowan, Katrina Anichtchik, Oleg Luo, Shouqing |
author_sort | Cowan, Katrina |
collection | PubMed |
description | The mitochondrion is a unique organelle with a diverse range of functions. Mitochondrial dysfunction is a key pathological process in several neurodegenerative diseases. Mitochondria are mostly important for energy production; however, they also have roles in Ca(2+) homeostasis, ROS production, and apoptosis. There are two major systems in place, which regulate mitochondrial integrity, mitochondrial dynamics, and mitophagy. These two processes remove damaged mitochondria from cells and protect the functional mitochondrial population. These quality control systems often become dysfunctional during neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, causing mitochondrial dysfunction and severe neurological symptoms. |
format | Online Article Text |
id | pubmed-6566061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65660612019-06-26 Mitochondrial integrity in neurodegeneration Cowan, Katrina Anichtchik, Oleg Luo, Shouqing CNS Neurosci Ther Review Articles The mitochondrion is a unique organelle with a diverse range of functions. Mitochondrial dysfunction is a key pathological process in several neurodegenerative diseases. Mitochondria are mostly important for energy production; however, they also have roles in Ca(2+) homeostasis, ROS production, and apoptosis. There are two major systems in place, which regulate mitochondrial integrity, mitochondrial dynamics, and mitophagy. These two processes remove damaged mitochondria from cells and protect the functional mitochondrial population. These quality control systems often become dysfunctional during neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, causing mitochondrial dysfunction and severe neurological symptoms. John Wiley and Sons Inc. 2019-02-11 /pmc/articles/PMC6566061/ /pubmed/30746905 http://dx.doi.org/10.1111/cns.13105 Text en © 2019 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Cowan, Katrina Anichtchik, Oleg Luo, Shouqing Mitochondrial integrity in neurodegeneration |
title | Mitochondrial integrity in neurodegeneration |
title_full | Mitochondrial integrity in neurodegeneration |
title_fullStr | Mitochondrial integrity in neurodegeneration |
title_full_unstemmed | Mitochondrial integrity in neurodegeneration |
title_short | Mitochondrial integrity in neurodegeneration |
title_sort | mitochondrial integrity in neurodegeneration |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566061/ https://www.ncbi.nlm.nih.gov/pubmed/30746905 http://dx.doi.org/10.1111/cns.13105 |
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