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Targeting extracellular glycans: tuning multimeric boronic acids for pathogen-selective killing of Mycobacterium tuberculosis

Innovative chemotherapeutic agents that are active against Mycobacterium tuberculosis (Mtb) are urgently required to control the tuberculosis (TB) epidemic. The Mtb cell envelope has distinct (lipo)polysaccharides and glycolipids that play a critical role in Mtb survival and pathogenesis and disrupt...

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Detalles Bibliográficos
Autores principales: Guy, Collette S., Gibson, Matthew I., Fullam, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566077/
https://www.ncbi.nlm.nih.gov/pubmed/31360399
http://dx.doi.org/10.1039/c9sc00415g