Cargando…

Targeting extracellular glycans: tuning multimeric boronic acids for pathogen-selective killing of Mycobacterium tuberculosis

Innovative chemotherapeutic agents that are active against Mycobacterium tuberculosis (Mtb) are urgently required to control the tuberculosis (TB) epidemic. The Mtb cell envelope has distinct (lipo)polysaccharides and glycolipids that play a critical role in Mtb survival and pathogenesis and disrupt...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guy, Collette S., Gibson, Matthew I., Fullam, Elizabeth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566077/ https://www.ncbi.nlm.nih.gov/pubmed/31360399 http://dx.doi.org/10.1039/c9sc00415g

Ejemplares similares

Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture
por: Guy, Collette S., et al.
Publicado: (2022)

Physicochemical properties and Mycobacterium tuberculosis transporters: keys to efficacious antitubercular drugs?
por: Fullam, Elizabeth, et al.
Publicado: (2020)

Targeting virulence: salmochelin modification tunes the antibacterial activity spectrum of β-lactams for pathogen-selective killing of Escherichia coli
por: Chairatana, Phoom, et al.
Publicado: (2015)

Osmium–arene complexes with high potency towards Mycobacterium tuberculosis
por: Coverdale, James P C, et al.
Publicado: (2021)

AC2P20 selectively kills Mycobacterium tuberculosis at acidic pH by depleting free thiols
por: Dechow, Shelby J., et al.
Publicado: (2021)

Structural Basis of Glycerophosphodiester Recognition by the Mycobacterium tuberculosis Substrate-Binding Protein UgpB
por: Fenn, Jonathan S., et al.
Publicado: (2019)

Interrogation of the Pathogen Box reveals small molecule ligands against the mycobacterial trehalose transporter LpqY-SugABC
por: Radhakrishnan, Anjana, et al.
Publicado: (2022)

Combinatorial design of multimeric chelating peptoids for selective metal coordination
por: Ricano, Abel, et al.
Publicado: (2019)

Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates
por: Toniolo, Chiara, et al.
Publicado: (2023)

Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA)
por: Ahangar, Mohd Syed, et al.
Publicado: (2018)

Tuning catalysis of boronic acids in microgels by in situ reversible structural variations
por: Zhai, Zhenghao, et al.
Publicado: (2020)

Electronic and valleytronic properties of crystalline boron-arsenide tuned by strain and disorder
por: Craco, L., et al.
Publicado: (2023)

Xanthohumol from Humulus lupulus L. potentiates the killing of Mycobacterium tuberculosis and mitigates liver toxicity by the combination of isoniazid in mouse tuberculosis models
por: Lou, Hai, et al.
Publicado: (2020)

A GFP-strategy for efficient recombinant protein overexpression and purification in Mycobacterium smegmatis
por: Radhakrishnan, Anjana, et al.
Publicado: (2018)

The Potential of Modified and Multimeric Antimicrobial Peptide Materials as Superbug Killers
por: Matthyssen, Tamara, et al.
Publicado: (2022)

Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands
por: Richards, Sarah-Jane, et al.
Publicado: (2020)

Beyond Killing Mycobacterium tuberculosis: Disease Tolerance
por: Divangahi, Maziar, et al.
Publicado: (2018)

Potentiation of TRAIL killing activity by multimerization through isoleucine zipper hexamerization motif
por: Han, Ji Hye, et al.
Publicado: (2016)

Neutrophil killing of Mycobacterium abscessus by intra- and extracellular mechanisms
por: Malcolm, Kenneth C., et al.
Publicado: (2018)

Cryo-EM structure of acylpeptide hydrolase reveals substrate selection by multimerization and a multi-state serine-protease triad
por: Kiss-Szemán, Anna J., et al.
Publicado: (2022)

Multimerization rules for G-quadruplexes
por: Kolesnikova, Sofia, et al.
Publicado: (2017)

Automated glycan assembly of arabinomannan oligosaccharides from Mycobacterium tuberculosis
por: Pardo-Vargas, Alonso, et al.
Publicado: (2019)

Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens
por: Cebrián, Rubén, et al.
Publicado: (2022)

Fine-tuning the spike: role of the nature and topology of the glycan shield in the structure and dynamics of the SARS-CoV-2 S
por: Harbison, Aoife M., et al.
Publicado: (2021)

Analysis of binding properties of pathogens and toxins using multivalent glycan microarrays
por: Kim, Hyoung Sub, et al.
Publicado: (2018)

Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways
por: Simpson, Daniel H., et al.
Publicado: (2019)

Chemoselective oxidation of aryl organoboron systems enabled by boronic acid-selective phase transfer
por: Molloy, John J., et al.
Publicado: (2017)

meta-Selective C–H functionalisation of aryl boronic acids directed by a MIDA-derived boronate ester
por: Williams, Alexander F., et al.
Publicado: (2020)

Hydrophosphination of boron–boron multiple bonds
por: Stennett, Tom E., et al.
Publicado: (2019)

Examining and Fine-tuning the Selection of Glycan Compositions with GlyConnect Compozitor
por: Robin, Thibault, et al.
Publicado: (2020)

Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile
por: Otten, Lucienne, et al.
Publicado: (2016)

A straightforward synthesis of phenyl boronic acid (PBA) containing BODIPY dyes: new functional and modular fluorescent tools for the tethering of the glycan domain of antibodies
por: Giacomazzo, Gina Elena, et al.
Publicado: (2019)

Glycan–protein interactions determine kinetics of N-glycan remodeling
por: Mathew, Corina, et al.
Publicado: (2021)

Fine-Tuning Tumor Endothelial Cells to Selectively Kill Cancer
por: Uldry, Emilie, et al.
Publicado: (2017)

EthA/R-Independent Killing of Mycobacterium tuberculosis by Ethionamide
por: Ang, Michelle L. T., et al.
Publicado: (2017)

Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis
por: Hawerkamp, Heike C., et al.
Publicado: (2020)

SK-03-92 Drug Kills Intracellular Mycobacterium tuberculosis
por: Schwan, William R.
Publicado: (2023)

Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme
por: Fullam, Elizabeth, et al.
Publicado: (2012)

Tuning the binding behaviors of a protein YAP65WW domain on graphenic nano-sheets with boron or nitrogen atom doping
por: Jia, Xiao, et al.
Publicado: (2020)

Glycan Microarrays as Chemical Tools for Identifying Glycan Recognition by Immune Proteins
por: Gao, Chao, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_p86pu9f0j01shhm9mh0j38ha9q