Cytoplasmic translocation of nuclear LSD1 (KDM1A) in human hepatoma cells is induced by its inhibitors

AIM: Histone-modifiable lysine-specific demethylase-1 (LSD1/KDM1A) is an oncoprotein upregulated in cancers, including hepatoma. We previously reported that the hepatoma-preventive geranylgeranoic acid (GGA) inhibits KDM1A at the same IC(50) as that of the clinically used tranylcypromine. Here, we r...

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Detalles Bibliográficos
Autores principales: Yabuta, Suemi, Shidoji, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566134/
https://www.ncbi.nlm.nih.gov/pubmed/31205679
http://dx.doi.org/10.2217/hep-2018-0008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566134/
https://www.ncbi.nlm.nih.gov/pubmed/31205679
http://dx.doi.org/10.2217/hep-2018-0008

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