Cargando…
Effects of interleukin‐6 receptor blockade on allergen‐induced airway responses in mild asthmatics
BACKGROUND: Interleukin (IL)‐6 signalling has been implicated in allergic asthma by animal, genetic association and clinical studies. In this study, we tested the hypothesis that tocilizumab (TCZ), a human monoclonal antibody that blocks IL‐6 signalling, can prevent the development of allergen‐induc...
Autores principales: | Revez, Joana A, Bain, Lisa M, Watson, Rick M, Towers, Michelle, Collins, Tina, Killian, Kieran J, O'Byrne, Paul M, Gauvreau, Gail M, Upham, John W, Ferreira, Manuel AR |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566140/ https://www.ncbi.nlm.nih.gov/pubmed/31223480 http://dx.doi.org/10.1002/cti2.1044 |
Ejemplares similares
-
Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects
por: Gauvreau, Gail M, et al.
Publicado: (2011) -
Cholinergic synapse pathway gene polymorphisms associated with allergen-induced late asthmatic responses
por: Rajasekaran, Ashwini, et al.
Publicado: (2019) -
Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge
por: Yamamoto, Masatsugu, et al.
Publicado: (2012) -
OX40L blockade and allergen-induced airway responses in subjects with mild asthma
por: Gauvreau, G M, et al.
Publicado: (2014) -
Th17/Treg ratio derived using DNA methylation analysis discriminates allergen-induced early from dual asthmatic responses
por: Singh, Amrit, et al.
Publicado: (2014)