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Do Transferrin Levels Predict Haemodialysis Adequacy in Patients with End-Stage Renal Disease?

Background: Since haemodialysis is a lifesaving therapy, adequate control measures are necessary to evaluate its adequacy and to constantly adjust the dose to reduce hospitalisation and prolong patient survival. Malnutrition is common in haemodialysis patients and closely related to morbidity and mo...

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Autores principales: Tarantino, Giovanni, Vinciguerra, Mauro, Ragosta, Annalisa, Citro, Vincenzo, Conforti, Paolo, Salvati, Giovanni, Sorrentino, Aniello, Barretta, Luca, Balsano, Clara, Capone, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566169/
https://www.ncbi.nlm.nih.gov/pubmed/31137583
http://dx.doi.org/10.3390/nu11051123
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author Tarantino, Giovanni
Vinciguerra, Mauro
Ragosta, Annalisa
Citro, Vincenzo
Conforti, Paolo
Salvati, Giovanni
Sorrentino, Aniello
Barretta, Luca
Balsano, Clara
Capone, Domenico
author_facet Tarantino, Giovanni
Vinciguerra, Mauro
Ragosta, Annalisa
Citro, Vincenzo
Conforti, Paolo
Salvati, Giovanni
Sorrentino, Aniello
Barretta, Luca
Balsano, Clara
Capone, Domenico
author_sort Tarantino, Giovanni
collection PubMed
description Background: Since haemodialysis is a lifesaving therapy, adequate control measures are necessary to evaluate its adequacy and to constantly adjust the dose to reduce hospitalisation and prolong patient survival. Malnutrition is common in haemodialysis patients and closely related to morbidity and mortality. Patients undergoing haemodialysis have a high prevalence of protein-energy malnutrition and inflammation, along with abnormal iron status. The haemodialysis dose delivered is an important predictor of patient outcome. Aim: To evaluate through haemodialysis adequacy, which parameter(s), if any, better predict Kt/V, among those used to assess nutritional status, inflammation response, and iron status. Methods: We retrospectively studied 78 patients undergoing haemodialysis due to end-stage renal disease. As parameters of nutritional status, geriatric nutritional risk index (GNRI), transferrin levels, lymphocyte count, and albumin concentration were analysed. As signs of inflammation, C reactive protein (CRP) levels and ferritin concentrations were studied as well. Iron status was evaluated by both transferrin and ferritin levels, as well as by haemoglobin (Hb) concentration. Results: The core finding of our retrospective study is that transferrin levels predict the adequacy of haemodialysis expressed as Kt/V; the latter is the only predictor (P = 0.001) when adjusting for CRP concentrations, a solid marker of inflammation, and for ferritin levels considered an iron-storage protein, but also a parameter of inflammatory response. Discussion and Conclusion: In keeping with the results of this study, we underline that the use of transferrin levels to assess haemodialysis quality combine into a single test the evaluation of the three most important factors of protein-energy wasting.
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spelling pubmed-65661692019-06-17 Do Transferrin Levels Predict Haemodialysis Adequacy in Patients with End-Stage Renal Disease? Tarantino, Giovanni Vinciguerra, Mauro Ragosta, Annalisa Citro, Vincenzo Conforti, Paolo Salvati, Giovanni Sorrentino, Aniello Barretta, Luca Balsano, Clara Capone, Domenico Nutrients Article Background: Since haemodialysis is a lifesaving therapy, adequate control measures are necessary to evaluate its adequacy and to constantly adjust the dose to reduce hospitalisation and prolong patient survival. Malnutrition is common in haemodialysis patients and closely related to morbidity and mortality. Patients undergoing haemodialysis have a high prevalence of protein-energy malnutrition and inflammation, along with abnormal iron status. The haemodialysis dose delivered is an important predictor of patient outcome. Aim: To evaluate through haemodialysis adequacy, which parameter(s), if any, better predict Kt/V, among those used to assess nutritional status, inflammation response, and iron status. Methods: We retrospectively studied 78 patients undergoing haemodialysis due to end-stage renal disease. As parameters of nutritional status, geriatric nutritional risk index (GNRI), transferrin levels, lymphocyte count, and albumin concentration were analysed. As signs of inflammation, C reactive protein (CRP) levels and ferritin concentrations were studied as well. Iron status was evaluated by both transferrin and ferritin levels, as well as by haemoglobin (Hb) concentration. Results: The core finding of our retrospective study is that transferrin levels predict the adequacy of haemodialysis expressed as Kt/V; the latter is the only predictor (P = 0.001) when adjusting for CRP concentrations, a solid marker of inflammation, and for ferritin levels considered an iron-storage protein, but also a parameter of inflammatory response. Discussion and Conclusion: In keeping with the results of this study, we underline that the use of transferrin levels to assess haemodialysis quality combine into a single test the evaluation of the three most important factors of protein-energy wasting. MDPI 2019-05-20 /pmc/articles/PMC6566169/ /pubmed/31137583 http://dx.doi.org/10.3390/nu11051123 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tarantino, Giovanni
Vinciguerra, Mauro
Ragosta, Annalisa
Citro, Vincenzo
Conforti, Paolo
Salvati, Giovanni
Sorrentino, Aniello
Barretta, Luca
Balsano, Clara
Capone, Domenico
Do Transferrin Levels Predict Haemodialysis Adequacy in Patients with End-Stage Renal Disease?
title Do Transferrin Levels Predict Haemodialysis Adequacy in Patients with End-Stage Renal Disease?
title_full Do Transferrin Levels Predict Haemodialysis Adequacy in Patients with End-Stage Renal Disease?
title_fullStr Do Transferrin Levels Predict Haemodialysis Adequacy in Patients with End-Stage Renal Disease?
title_full_unstemmed Do Transferrin Levels Predict Haemodialysis Adequacy in Patients with End-Stage Renal Disease?
title_short Do Transferrin Levels Predict Haemodialysis Adequacy in Patients with End-Stage Renal Disease?
title_sort do transferrin levels predict haemodialysis adequacy in patients with end-stage renal disease?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566169/
https://www.ncbi.nlm.nih.gov/pubmed/31137583
http://dx.doi.org/10.3390/nu11051123
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