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MicroRNA-Mediated Health-Promoting Effects of Phytochemicals
Phytochemicals are known to benefit human health by modulating various cellular processes, including cell proliferation, apoptosis, and inflammation. Due to the potential use of phytochemicals as therapeutic agents against human diseases such as cancer, studies are ongoing to elucidate the molecular...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566171/ https://www.ncbi.nlm.nih.gov/pubmed/31126043 http://dx.doi.org/10.3390/ijms20102535 |
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author | Kang, Hara |
author_facet | Kang, Hara |
author_sort | Kang, Hara |
collection | PubMed |
description | Phytochemicals are known to benefit human health by modulating various cellular processes, including cell proliferation, apoptosis, and inflammation. Due to the potential use of phytochemicals as therapeutic agents against human diseases such as cancer, studies are ongoing to elucidate the molecular mechanisms by which phytochemicals affect cellular functions. It has recently been shown that phytochemicals may regulate the expression of microRNAs (miRNAs). MiRNAs are responsible for the fine-tuning of gene expression by controlling the expression of their target mRNAs in both normal and pathological cells. This review summarizes the recent findings regarding phytochemicals that modulate miRNA expression and promote human health by exerting anticancer, photoprotective, and anti-hepatosteatosis effects. Identifying miRNAs modulated by phytochemicals and understanding the regulatory mechanisms mediated by their target mRNAs will facilitate the efforts to maximize the therapeutic benefits of phytochemicals. |
format | Online Article Text |
id | pubmed-6566171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65661712019-06-17 MicroRNA-Mediated Health-Promoting Effects of Phytochemicals Kang, Hara Int J Mol Sci Review Phytochemicals are known to benefit human health by modulating various cellular processes, including cell proliferation, apoptosis, and inflammation. Due to the potential use of phytochemicals as therapeutic agents against human diseases such as cancer, studies are ongoing to elucidate the molecular mechanisms by which phytochemicals affect cellular functions. It has recently been shown that phytochemicals may regulate the expression of microRNAs (miRNAs). MiRNAs are responsible for the fine-tuning of gene expression by controlling the expression of their target mRNAs in both normal and pathological cells. This review summarizes the recent findings regarding phytochemicals that modulate miRNA expression and promote human health by exerting anticancer, photoprotective, and anti-hepatosteatosis effects. Identifying miRNAs modulated by phytochemicals and understanding the regulatory mechanisms mediated by their target mRNAs will facilitate the efforts to maximize the therapeutic benefits of phytochemicals. MDPI 2019-05-23 /pmc/articles/PMC6566171/ /pubmed/31126043 http://dx.doi.org/10.3390/ijms20102535 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kang, Hara MicroRNA-Mediated Health-Promoting Effects of Phytochemicals |
title | MicroRNA-Mediated Health-Promoting Effects of Phytochemicals |
title_full | MicroRNA-Mediated Health-Promoting Effects of Phytochemicals |
title_fullStr | MicroRNA-Mediated Health-Promoting Effects of Phytochemicals |
title_full_unstemmed | MicroRNA-Mediated Health-Promoting Effects of Phytochemicals |
title_short | MicroRNA-Mediated Health-Promoting Effects of Phytochemicals |
title_sort | microrna-mediated health-promoting effects of phytochemicals |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566171/ https://www.ncbi.nlm.nih.gov/pubmed/31126043 http://dx.doi.org/10.3390/ijms20102535 |
work_keys_str_mv | AT kanghara micrornamediatedhealthpromotingeffectsofphytochemicals |