Cargando…

MicroRNA-Mediated Health-Promoting Effects of Phytochemicals

Phytochemicals are known to benefit human health by modulating various cellular processes, including cell proliferation, apoptosis, and inflammation. Due to the potential use of phytochemicals as therapeutic agents against human diseases such as cancer, studies are ongoing to elucidate the molecular...

Descripción completa

Detalles Bibliográficos
Autor principal: Kang, Hara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566171/
https://www.ncbi.nlm.nih.gov/pubmed/31126043
http://dx.doi.org/10.3390/ijms20102535
_version_ 1783426791846707200
author Kang, Hara
author_facet Kang, Hara
author_sort Kang, Hara
collection PubMed
description Phytochemicals are known to benefit human health by modulating various cellular processes, including cell proliferation, apoptosis, and inflammation. Due to the potential use of phytochemicals as therapeutic agents against human diseases such as cancer, studies are ongoing to elucidate the molecular mechanisms by which phytochemicals affect cellular functions. It has recently been shown that phytochemicals may regulate the expression of microRNAs (miRNAs). MiRNAs are responsible for the fine-tuning of gene expression by controlling the expression of their target mRNAs in both normal and pathological cells. This review summarizes the recent findings regarding phytochemicals that modulate miRNA expression and promote human health by exerting anticancer, photoprotective, and anti-hepatosteatosis effects. Identifying miRNAs modulated by phytochemicals and understanding the regulatory mechanisms mediated by their target mRNAs will facilitate the efforts to maximize the therapeutic benefits of phytochemicals.
format Online
Article
Text
id pubmed-6566171
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-65661712019-06-17 MicroRNA-Mediated Health-Promoting Effects of Phytochemicals Kang, Hara Int J Mol Sci Review Phytochemicals are known to benefit human health by modulating various cellular processes, including cell proliferation, apoptosis, and inflammation. Due to the potential use of phytochemicals as therapeutic agents against human diseases such as cancer, studies are ongoing to elucidate the molecular mechanisms by which phytochemicals affect cellular functions. It has recently been shown that phytochemicals may regulate the expression of microRNAs (miRNAs). MiRNAs are responsible for the fine-tuning of gene expression by controlling the expression of their target mRNAs in both normal and pathological cells. This review summarizes the recent findings regarding phytochemicals that modulate miRNA expression and promote human health by exerting anticancer, photoprotective, and anti-hepatosteatosis effects. Identifying miRNAs modulated by phytochemicals and understanding the regulatory mechanisms mediated by their target mRNAs will facilitate the efforts to maximize the therapeutic benefits of phytochemicals. MDPI 2019-05-23 /pmc/articles/PMC6566171/ /pubmed/31126043 http://dx.doi.org/10.3390/ijms20102535 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kang, Hara
MicroRNA-Mediated Health-Promoting Effects of Phytochemicals
title MicroRNA-Mediated Health-Promoting Effects of Phytochemicals
title_full MicroRNA-Mediated Health-Promoting Effects of Phytochemicals
title_fullStr MicroRNA-Mediated Health-Promoting Effects of Phytochemicals
title_full_unstemmed MicroRNA-Mediated Health-Promoting Effects of Phytochemicals
title_short MicroRNA-Mediated Health-Promoting Effects of Phytochemicals
title_sort microrna-mediated health-promoting effects of phytochemicals
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566171/
https://www.ncbi.nlm.nih.gov/pubmed/31126043
http://dx.doi.org/10.3390/ijms20102535
work_keys_str_mv AT kanghara micrornamediatedhealthpromotingeffectsofphytochemicals