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KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders
The underlying molecular basis for neurodevelopmental or neuropsychiatric disorders is not known. In contrast, mechanistic understanding of other brain disorders including neurodegeneration has advanced considerably. Yet, these do not approach the knowledge accrued for many cancers with precision th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566181/ https://www.ncbi.nlm.nih.gov/pubmed/31197948 http://dx.doi.org/10.1111/cns.13156 |
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author | Teng, Xinchen Aouacheria, Abdel Lionnard, Loïc Metz, Kyle A. Soane, Lucian Kamiya, Atsushi Hardwick, J. Marie |
author_facet | Teng, Xinchen Aouacheria, Abdel Lionnard, Loïc Metz, Kyle A. Soane, Lucian Kamiya, Atsushi Hardwick, J. Marie |
author_sort | Teng, Xinchen |
collection | PubMed |
description | The underlying molecular basis for neurodevelopmental or neuropsychiatric disorders is not known. In contrast, mechanistic understanding of other brain disorders including neurodegeneration has advanced considerably. Yet, these do not approach the knowledge accrued for many cancers with precision therapeutics acting on well‐characterized targets. Although the identification of genes responsible for neurodevelopmental and neuropsychiatric disorders remains a major obstacle, the few causally associated genes are ripe for discovery by focusing efforts to dissect their mechanisms. Here, we make a case for delving into mechanisms of the poorly characterized human KCTD gene family. Varying levels of evidence support their roles in neurocognitive disorders (KCTD3), neurodevelopmental disease (KCTD7), bipolar disorder (KCTD12), autism and schizophrenia (KCTD13), movement disorders (KCTD17), cancer (KCTD11), and obesity (KCTD15). Collective knowledge about these genes adds enhanced value, and critical insights into potential disease mechanisms have come from unexpected sources. Translation of basic research on the KCTD‐related yeast protein Whi2 has revealed roles in nutrient signaling to mTORC1 (KCTD11) and an autophagy‐lysosome pathway affecting mitochondria (KCTD7). Recent biochemical and structure‐based studies (KCTD12, KCTD13, KCTD16) reveal mechanisms of regulating membrane channel activities through modulation of distinct GTPases. We explore how these seemingly varied functions may be disease related. |
format | Online Article Text |
id | pubmed-6566181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65661812019-06-26 KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders Teng, Xinchen Aouacheria, Abdel Lionnard, Loïc Metz, Kyle A. Soane, Lucian Kamiya, Atsushi Hardwick, J. Marie CNS Neurosci Ther Review Articles The underlying molecular basis for neurodevelopmental or neuropsychiatric disorders is not known. In contrast, mechanistic understanding of other brain disorders including neurodegeneration has advanced considerably. Yet, these do not approach the knowledge accrued for many cancers with precision therapeutics acting on well‐characterized targets. Although the identification of genes responsible for neurodevelopmental and neuropsychiatric disorders remains a major obstacle, the few causally associated genes are ripe for discovery by focusing efforts to dissect their mechanisms. Here, we make a case for delving into mechanisms of the poorly characterized human KCTD gene family. Varying levels of evidence support their roles in neurocognitive disorders (KCTD3), neurodevelopmental disease (KCTD7), bipolar disorder (KCTD12), autism and schizophrenia (KCTD13), movement disorders (KCTD17), cancer (KCTD11), and obesity (KCTD15). Collective knowledge about these genes adds enhanced value, and critical insights into potential disease mechanisms have come from unexpected sources. Translation of basic research on the KCTD‐related yeast protein Whi2 has revealed roles in nutrient signaling to mTORC1 (KCTD11) and an autophagy‐lysosome pathway affecting mitochondria (KCTD7). Recent biochemical and structure‐based studies (KCTD12, KCTD13, KCTD16) reveal mechanisms of regulating membrane channel activities through modulation of distinct GTPases. We explore how these seemingly varied functions may be disease related. John Wiley and Sons Inc. 2019-06-14 /pmc/articles/PMC6566181/ /pubmed/31197948 http://dx.doi.org/10.1111/cns.13156 Text en © 2019 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Teng, Xinchen Aouacheria, Abdel Lionnard, Loïc Metz, Kyle A. Soane, Lucian Kamiya, Atsushi Hardwick, J. Marie KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders |
title |
KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders |
title_full |
KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders |
title_fullStr |
KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders |
title_full_unstemmed |
KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders |
title_short |
KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders |
title_sort | kctd: a new gene family involved in neurodevelopmental and neuropsychiatric disorders |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566181/ https://www.ncbi.nlm.nih.gov/pubmed/31197948 http://dx.doi.org/10.1111/cns.13156 |
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