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Comparing Properties of Variable Pore-Sized 3D-Printed PLA Membrane with Conventional PLA Membrane for Guided Bone/Tissue Regeneration

The aim of this study was to fabricate bioresorbable polylactide (PLA) membranes by 3D printing and compare their properties to those of the membranes fabricated by the conventional method and compare the effect of different pore sizes on the properties of the 3D-printed membranes. PLA membranes wit...

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Detalles Bibliográficos
Autores principales: Zhang, Hao Yang, Jiang, Heng Bo, Ryu, Jeong-Hyun, Kang, Hyojin, Kim, Kwang-Mahn, Kwon, Jae-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566256/
https://www.ncbi.nlm.nih.gov/pubmed/31137830
http://dx.doi.org/10.3390/ma12101718
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author Zhang, Hao Yang
Jiang, Heng Bo
Ryu, Jeong-Hyun
Kang, Hyojin
Kim, Kwang-Mahn
Kwon, Jae-Sung
author_facet Zhang, Hao Yang
Jiang, Heng Bo
Ryu, Jeong-Hyun
Kang, Hyojin
Kim, Kwang-Mahn
Kwon, Jae-Sung
author_sort Zhang, Hao Yang
collection PubMed
description The aim of this study was to fabricate bioresorbable polylactide (PLA) membranes by 3D printing and compare their properties to those of the membranes fabricated by the conventional method and compare the effect of different pore sizes on the properties of the 3D-printed membranes. PLA membranes with three different pore sizes (large pore-479 μm, small pore-273 μm, and no pore) were 3D printed, and membranes fabricated using the conventional solvent casting method were used as the control group. Scanning electron microscopy (SEM) and micro-computed tomography (µ-CT) were taken to observe the morphology and obtain the porosity of the four groups. A tensile test was performed to compare the tensile strength, elastic modulus, and elongation at break of the membranes. Preosteoblast cells were cultured on the membranes for 1, 3 and 7 days, followed by a WST assay and SEM, to examine the cell proliferation on different groups. As a result, the 3D-printed membranes showed superior mechanical properties to those of the solvent cast membranes, and the 3D-printed membranes exhibited different advantageous mechanical properties depending on the different pore sizes. The various fabrication methods and pore sizes did not have significantly different effects on cell growth. It is proven that 3D printing is a promising method for the fabrication of customized barrier membranes used in GBR/GTR.
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spelling pubmed-65662562019-06-17 Comparing Properties of Variable Pore-Sized 3D-Printed PLA Membrane with Conventional PLA Membrane for Guided Bone/Tissue Regeneration Zhang, Hao Yang Jiang, Heng Bo Ryu, Jeong-Hyun Kang, Hyojin Kim, Kwang-Mahn Kwon, Jae-Sung Materials (Basel) Article The aim of this study was to fabricate bioresorbable polylactide (PLA) membranes by 3D printing and compare their properties to those of the membranes fabricated by the conventional method and compare the effect of different pore sizes on the properties of the 3D-printed membranes. PLA membranes with three different pore sizes (large pore-479 μm, small pore-273 μm, and no pore) were 3D printed, and membranes fabricated using the conventional solvent casting method were used as the control group. Scanning electron microscopy (SEM) and micro-computed tomography (µ-CT) were taken to observe the morphology and obtain the porosity of the four groups. A tensile test was performed to compare the tensile strength, elastic modulus, and elongation at break of the membranes. Preosteoblast cells were cultured on the membranes for 1, 3 and 7 days, followed by a WST assay and SEM, to examine the cell proliferation on different groups. As a result, the 3D-printed membranes showed superior mechanical properties to those of the solvent cast membranes, and the 3D-printed membranes exhibited different advantageous mechanical properties depending on the different pore sizes. The various fabrication methods and pore sizes did not have significantly different effects on cell growth. It is proven that 3D printing is a promising method for the fabrication of customized barrier membranes used in GBR/GTR. MDPI 2019-05-27 /pmc/articles/PMC6566256/ /pubmed/31137830 http://dx.doi.org/10.3390/ma12101718 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Hao Yang
Jiang, Heng Bo
Ryu, Jeong-Hyun
Kang, Hyojin
Kim, Kwang-Mahn
Kwon, Jae-Sung
Comparing Properties of Variable Pore-Sized 3D-Printed PLA Membrane with Conventional PLA Membrane for Guided Bone/Tissue Regeneration
title Comparing Properties of Variable Pore-Sized 3D-Printed PLA Membrane with Conventional PLA Membrane for Guided Bone/Tissue Regeneration
title_full Comparing Properties of Variable Pore-Sized 3D-Printed PLA Membrane with Conventional PLA Membrane for Guided Bone/Tissue Regeneration
title_fullStr Comparing Properties of Variable Pore-Sized 3D-Printed PLA Membrane with Conventional PLA Membrane for Guided Bone/Tissue Regeneration
title_full_unstemmed Comparing Properties of Variable Pore-Sized 3D-Printed PLA Membrane with Conventional PLA Membrane for Guided Bone/Tissue Regeneration
title_short Comparing Properties of Variable Pore-Sized 3D-Printed PLA Membrane with Conventional PLA Membrane for Guided Bone/Tissue Regeneration
title_sort comparing properties of variable pore-sized 3d-printed pla membrane with conventional pla membrane for guided bone/tissue regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566256/
https://www.ncbi.nlm.nih.gov/pubmed/31137830
http://dx.doi.org/10.3390/ma12101718
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