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Modelling peeling- and pressure-driven propagation of arterial dissection
An arterial dissection is a longitudinal tear in the vessel wall, which can create a false lumen for blood flow and may propagate quickly, leading to death. We employ a computational model for a dissection using the extended finite element method with a cohesive traction-separation law for the tear...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566306/ https://www.ncbi.nlm.nih.gov/pubmed/31258175 http://dx.doi.org/10.1007/s10665-017-9948-0 |
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author | Wang, Lei Hill, Nicholas A. Roper, Steven M. Luo, Xiaoyu |
author_facet | Wang, Lei Hill, Nicholas A. Roper, Steven M. Luo, Xiaoyu |
author_sort | Wang, Lei |
collection | PubMed |
description | An arterial dissection is a longitudinal tear in the vessel wall, which can create a false lumen for blood flow and may propagate quickly, leading to death. We employ a computational model for a dissection using the extended finite element method with a cohesive traction-separation law for the tear faces. The arterial wall is described by the anisotropic hyperelastic Holzapfel–Gasser–Ogden material model that accounts for collagen fibres and ground matrix, while the evolution of damage is governed by a linear cohesive traction-separation law. We simulate propagation in both peeling and pressure-loading tests. For peeling tests, we consider strips and discs cut from the arterial wall. Propagation is found to occur preferentially along the material axes with the greatest stiffness, which are determined by the fibre orientation. In the case of pressure-driven propagation, we examine a cylindrical model, with an initial tear in the shape of an arc. Long and shallow dissections lead to buckling of the inner wall between the true lumen and the dissection. The various buckling configurations closely match those seen in clinical CT scans. Our results also indicate that a deeper tear is more likely to propagate. |
format | Online Article Text |
id | pubmed-6566306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-65663062019-06-28 Modelling peeling- and pressure-driven propagation of arterial dissection Wang, Lei Hill, Nicholas A. Roper, Steven M. Luo, Xiaoyu J Eng Math Article An arterial dissection is a longitudinal tear in the vessel wall, which can create a false lumen for blood flow and may propagate quickly, leading to death. We employ a computational model for a dissection using the extended finite element method with a cohesive traction-separation law for the tear faces. The arterial wall is described by the anisotropic hyperelastic Holzapfel–Gasser–Ogden material model that accounts for collagen fibres and ground matrix, while the evolution of damage is governed by a linear cohesive traction-separation law. We simulate propagation in both peeling and pressure-loading tests. For peeling tests, we consider strips and discs cut from the arterial wall. Propagation is found to occur preferentially along the material axes with the greatest stiffness, which are determined by the fibre orientation. In the case of pressure-driven propagation, we examine a cylindrical model, with an initial tear in the shape of an arc. Long and shallow dissections lead to buckling of the inner wall between the true lumen and the dissection. The various buckling configurations closely match those seen in clinical CT scans. Our results also indicate that a deeper tear is more likely to propagate. Springer Netherlands 2017-12-13 2018 /pmc/articles/PMC6566306/ /pubmed/31258175 http://dx.doi.org/10.1007/s10665-017-9948-0 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Article Wang, Lei Hill, Nicholas A. Roper, Steven M. Luo, Xiaoyu Modelling peeling- and pressure-driven propagation of arterial dissection |
title | Modelling peeling- and pressure-driven propagation of arterial dissection |
title_full | Modelling peeling- and pressure-driven propagation of arterial dissection |
title_fullStr | Modelling peeling- and pressure-driven propagation of arterial dissection |
title_full_unstemmed | Modelling peeling- and pressure-driven propagation of arterial dissection |
title_short | Modelling peeling- and pressure-driven propagation of arterial dissection |
title_sort | modelling peeling- and pressure-driven propagation of arterial dissection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566306/ https://www.ncbi.nlm.nih.gov/pubmed/31258175 http://dx.doi.org/10.1007/s10665-017-9948-0 |
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