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Modelling peeling- and pressure-driven propagation of arterial dissection

An arterial dissection is a longitudinal tear in the vessel wall, which can create a false lumen for blood flow and may propagate quickly, leading to death. We employ a computational model for a dissection using the extended finite element method with a cohesive traction-separation law for the tear...

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Autores principales: Wang, Lei, Hill, Nicholas A., Roper, Steven M., Luo, Xiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566306/
https://www.ncbi.nlm.nih.gov/pubmed/31258175
http://dx.doi.org/10.1007/s10665-017-9948-0
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author Wang, Lei
Hill, Nicholas A.
Roper, Steven M.
Luo, Xiaoyu
author_facet Wang, Lei
Hill, Nicholas A.
Roper, Steven M.
Luo, Xiaoyu
author_sort Wang, Lei
collection PubMed
description An arterial dissection is a longitudinal tear in the vessel wall, which can create a false lumen for blood flow and may propagate quickly, leading to death. We employ a computational model for a dissection using the extended finite element method with a cohesive traction-separation law for the tear faces. The arterial wall is described by the anisotropic hyperelastic Holzapfel–Gasser–Ogden material model that accounts for collagen fibres and ground matrix, while the evolution of damage is governed by a linear cohesive traction-separation law. We simulate propagation in both peeling and pressure-loading tests. For peeling tests, we consider strips and discs cut from the arterial wall. Propagation is found to occur preferentially along the material axes with the greatest stiffness, which are determined by the fibre orientation. In the case of pressure-driven propagation, we examine a cylindrical model, with an initial tear in the shape of an arc. Long and shallow dissections lead to buckling of the inner wall between the true lumen and the dissection. The various buckling configurations closely match those seen in clinical CT scans. Our results also indicate that a deeper tear is more likely to propagate.
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spelling pubmed-65663062019-06-28 Modelling peeling- and pressure-driven propagation of arterial dissection Wang, Lei Hill, Nicholas A. Roper, Steven M. Luo, Xiaoyu J Eng Math Article An arterial dissection is a longitudinal tear in the vessel wall, which can create a false lumen for blood flow and may propagate quickly, leading to death. We employ a computational model for a dissection using the extended finite element method with a cohesive traction-separation law for the tear faces. The arterial wall is described by the anisotropic hyperelastic Holzapfel–Gasser–Ogden material model that accounts for collagen fibres and ground matrix, while the evolution of damage is governed by a linear cohesive traction-separation law. We simulate propagation in both peeling and pressure-loading tests. For peeling tests, we consider strips and discs cut from the arterial wall. Propagation is found to occur preferentially along the material axes with the greatest stiffness, which are determined by the fibre orientation. In the case of pressure-driven propagation, we examine a cylindrical model, with an initial tear in the shape of an arc. Long and shallow dissections lead to buckling of the inner wall between the true lumen and the dissection. The various buckling configurations closely match those seen in clinical CT scans. Our results also indicate that a deeper tear is more likely to propagate. Springer Netherlands 2017-12-13 2018 /pmc/articles/PMC6566306/ /pubmed/31258175 http://dx.doi.org/10.1007/s10665-017-9948-0 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Wang, Lei
Hill, Nicholas A.
Roper, Steven M.
Luo, Xiaoyu
Modelling peeling- and pressure-driven propagation of arterial dissection
title Modelling peeling- and pressure-driven propagation of arterial dissection
title_full Modelling peeling- and pressure-driven propagation of arterial dissection
title_fullStr Modelling peeling- and pressure-driven propagation of arterial dissection
title_full_unstemmed Modelling peeling- and pressure-driven propagation of arterial dissection
title_short Modelling peeling- and pressure-driven propagation of arterial dissection
title_sort modelling peeling- and pressure-driven propagation of arterial dissection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566306/
https://www.ncbi.nlm.nih.gov/pubmed/31258175
http://dx.doi.org/10.1007/s10665-017-9948-0
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