Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors

Background. The KEAP1/NRF2 pathway has been widely investigated in tumors since it was implicated in cancer cells survival and therapies resistance. In lung tumors the deregulation of this pathway is mainly related to point mutations of KEAP1 and NFE2L2 genes and KEAP1 promoter hypermethylation, but...

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Detalles Bibliográficos
Autores principales: Sparaneo, Angelo, Fabrizio, Federico Pio, la Torre, Annamaria, Graziano, Paolo, Di Maio, Massimo, Fontana, Andrea, Bisceglia, Michele, Rossi, Antonio, Pizzolitto, Stefano, De Maglio, Giovanna, Tancredi, Antonio, Grimaldi, Franco, Balsamo, Teresa, Centra, Flavia, Manzorra, Maria Carmina, Trombetta, Domenico, Pantalone, Angela, Bonfitto, Antonio, Maiello, Evaristo, Fazio, Vito Michele, Muscarella, Lucia Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566555/
https://www.ncbi.nlm.nih.gov/pubmed/31126053
http://dx.doi.org/10.3390/ijms20102531

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