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PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase

Indoleamine 2,3-dioxygenase (IDO) is an immunomodulating enzyme that is overexpressed in many cancers with poor prognosis. IDO suppresses T cell immunity by catabolizing tryptophan into kynurenine (KYN), which induces apoptosis in T effector cells and enhances T regulatory cells, providing a powerfu...

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Detalles Bibliográficos
Autores principales:	Huang, George Lo, Tao, Anqi, Miyazaki, Takuya, Khan, Thahomina, Hong, Taehun, Nakagawa, Yasuhiro, Cabral, Horacio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566635/ https://www.ncbi.nlm.nih.gov/pubmed/31075929 http://dx.doi.org/10.3390/nano9050719

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