Cargando…
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Late-stage Age-Related Macular Degeneration
Purpose: Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in Western Countries. Evidence indicates that Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency, a common genetic abnormality, may protect against ischemic heart and cerebrovascular disease, ocular vas...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566738/ https://www.ncbi.nlm.nih.gov/pubmed/31217728 http://dx.doi.org/10.7150/ijms.30155 |
_version_ | 1783426917518540800 |
---|---|
author | Pinna, Antonio Solinas, Giuliana Giancipoli, Ermete Porcu, Tiziana Zinellu, Angelo D'Amico-Ricci, Giuseppe Boscia, Francesco Lanzetta, Paolo Avitabile, Teresio Schwartz, Arthur G. Carru, Ciriaco |
author_facet | Pinna, Antonio Solinas, Giuliana Giancipoli, Ermete Porcu, Tiziana Zinellu, Angelo D'Amico-Ricci, Giuseppe Boscia, Francesco Lanzetta, Paolo Avitabile, Teresio Schwartz, Arthur G. Carru, Ciriaco |
author_sort | Pinna, Antonio |
collection | PubMed |
description | Purpose: Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in Western Countries. Evidence indicates that Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency, a common genetic abnormality, may protect against ischemic heart and cerebrovascular disease, ocular vascular disorders, and colorectal cancer. This study was undertaken to ascertain whether G6PD deficiency may protect against AMD. Materials and Methods: 79 men with late-stage AMD and 79 male, age-matched cataract controls without AMD were recruited in March-December 2016. Smoking status, clinical history, and drug use were recorded. A blood sample was taken from each participant. Complete blood count, hemoglobin, glucose, creatinine, cholesterol, triglycerides, transaminases, bilirubin, and erythrocyte G6PD activity were measured. Stepwise logistic regression was used to investigate the association between G6PD deficiency and AMD. Results: G6PD deficiency was found in 7 (8.9%) AMD patients and 8 (10.1%) controls, a not statistically significant difference. Stepwise logistic regression disclosed that AMD was significantly associated with increased diastolic blood pressure (OR=1.09, 95% CI=1.03-1.15, P=0.02) and LDL-cholesterol (OR=1.02, 95% CI=1.0001-1.03, P=0.049) and lower values of white blood cell (WBC) count (OR=0.71, 95% CI=0.56-0.88, P=0.02) and aspartate aminotransferase (AST) (OR=0.92, 95% CI=0.85-0.99, P=0.044). Conclusion: Results suggest that G6PD deficiency has no protective effect on nor is a risk factor for AMD. Larger studies are necessary to confirm whether increased diastolic blood pressure and LDL-cholesterol and lower values of WBC count and AST are risk factors for AMD. |
format | Online Article Text |
id | pubmed-6566738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-65667382019-06-19 Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Late-stage Age-Related Macular Degeneration Pinna, Antonio Solinas, Giuliana Giancipoli, Ermete Porcu, Tiziana Zinellu, Angelo D'Amico-Ricci, Giuseppe Boscia, Francesco Lanzetta, Paolo Avitabile, Teresio Schwartz, Arthur G. Carru, Ciriaco Int J Med Sci Research Paper Purpose: Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in Western Countries. Evidence indicates that Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency, a common genetic abnormality, may protect against ischemic heart and cerebrovascular disease, ocular vascular disorders, and colorectal cancer. This study was undertaken to ascertain whether G6PD deficiency may protect against AMD. Materials and Methods: 79 men with late-stage AMD and 79 male, age-matched cataract controls without AMD were recruited in March-December 2016. Smoking status, clinical history, and drug use were recorded. A blood sample was taken from each participant. Complete blood count, hemoglobin, glucose, creatinine, cholesterol, triglycerides, transaminases, bilirubin, and erythrocyte G6PD activity were measured. Stepwise logistic regression was used to investigate the association between G6PD deficiency and AMD. Results: G6PD deficiency was found in 7 (8.9%) AMD patients and 8 (10.1%) controls, a not statistically significant difference. Stepwise logistic regression disclosed that AMD was significantly associated with increased diastolic blood pressure (OR=1.09, 95% CI=1.03-1.15, P=0.02) and LDL-cholesterol (OR=1.02, 95% CI=1.0001-1.03, P=0.049) and lower values of white blood cell (WBC) count (OR=0.71, 95% CI=0.56-0.88, P=0.02) and aspartate aminotransferase (AST) (OR=0.92, 95% CI=0.85-0.99, P=0.044). Conclusion: Results suggest that G6PD deficiency has no protective effect on nor is a risk factor for AMD. Larger studies are necessary to confirm whether increased diastolic blood pressure and LDL-cholesterol and lower values of WBC count and AST are risk factors for AMD. Ivyspring International Publisher 2019-05-07 /pmc/articles/PMC6566738/ /pubmed/31217728 http://dx.doi.org/10.7150/ijms.30155 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Pinna, Antonio Solinas, Giuliana Giancipoli, Ermete Porcu, Tiziana Zinellu, Angelo D'Amico-Ricci, Giuseppe Boscia, Francesco Lanzetta, Paolo Avitabile, Teresio Schwartz, Arthur G. Carru, Ciriaco Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Late-stage Age-Related Macular Degeneration |
title | Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Late-stage Age-Related Macular Degeneration |
title_full | Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Late-stage Age-Related Macular Degeneration |
title_fullStr | Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Late-stage Age-Related Macular Degeneration |
title_full_unstemmed | Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Late-stage Age-Related Macular Degeneration |
title_short | Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Late-stage Age-Related Macular Degeneration |
title_sort | glucose-6-phosphate dehydrogenase (g6pd) deficiency and late-stage age-related macular degeneration |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566738/ https://www.ncbi.nlm.nih.gov/pubmed/31217728 http://dx.doi.org/10.7150/ijms.30155 |
work_keys_str_mv | AT pinnaantonio glucose6phosphatedehydrogenaseg6pddeficiencyandlatestageagerelatedmaculardegeneration AT solinasgiuliana glucose6phosphatedehydrogenaseg6pddeficiencyandlatestageagerelatedmaculardegeneration AT giancipoliermete glucose6phosphatedehydrogenaseg6pddeficiencyandlatestageagerelatedmaculardegeneration AT porcutiziana glucose6phosphatedehydrogenaseg6pddeficiencyandlatestageagerelatedmaculardegeneration AT zinelluangelo glucose6phosphatedehydrogenaseg6pddeficiencyandlatestageagerelatedmaculardegeneration AT damicoriccigiuseppe glucose6phosphatedehydrogenaseg6pddeficiencyandlatestageagerelatedmaculardegeneration AT bosciafrancesco glucose6phosphatedehydrogenaseg6pddeficiencyandlatestageagerelatedmaculardegeneration AT lanzettapaolo glucose6phosphatedehydrogenaseg6pddeficiencyandlatestageagerelatedmaculardegeneration AT avitabileteresio glucose6phosphatedehydrogenaseg6pddeficiencyandlatestageagerelatedmaculardegeneration AT schwartzarthurg glucose6phosphatedehydrogenaseg6pddeficiencyandlatestageagerelatedmaculardegeneration AT carruciriaco glucose6phosphatedehydrogenaseg6pddeficiencyandlatestageagerelatedmaculardegeneration |