Cargando…

Mitochondrial-Derived Vesicles as Candidate Biomarkers in Parkinson’s Disease: Rationale, Design and Methods of the EXosomes in PArkiNson Disease (EXPAND) Study

The progressive loss of dopaminergic neurons in the nigro-striatal system is a major trait of Parkinson’s disease (PD), manifesting clinically as motor and non-motor symptoms. Mitochondrial dysfunction and oxidative stress are alleged pathogenic mechanisms underlying aggregation of misfolded α-synuc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Picca, Anna, Guerra, Flora, Calvani, Riccardo, Bucci, Cecilia, Lo Monaco, Maria Rita, Bentivoglio, Anna Rita, Landi, Francesco, Bernabei, Roberto, Marzetti, Emanuele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Perspective
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566801/ https://www.ncbi.nlm.nih.gov/pubmed/31091653 http://dx.doi.org/10.3390/ijms20102373

Ejemplares similares

Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson’s Disease: Results from the EXosomes in PArkiNson’s Disease (EXPAND) Study
por: Picca, Anna, et al.
Publicado: (2020)

Mitochondrial Dysfunction and Aging: Insights from the Analysis of Extracellular Vesicles
por: Picca, Anna, et al.
Publicado: (2019)

Mitochondrial Dysfunction, Protein Misfolding and Neuroinflammation in Parkinson’s Disease: Roads to Biomarker Discovery
por: Picca, Anna, et al.
Publicado: (2021)

Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease
por: Picca, Anna, et al.
Publicado: (2020)

Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease
por: Picca, Anna, et al.
Publicado: (2020)

Of Microbes and Minds: A Narrative Review on the Second Brain Aging
por: Calvani, Riccardo, et al.
Publicado: (2018)

Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature
por: Picca, Anna, et al.
Publicado: (2020)

Mitochondrial-Derived Vesicles: The Good, the Bad, and the Ugly
por: Picca, Anna, et al.
Publicado: (2023)

Circulating Mitochondrial-Derived Vesicles, Inflammatory Biomarkers and Amino Acids in Older Adults With Physical Frailty and Sarcopenia: A Preliminary BIOSPHERE Multi-Marker Study Using Sequential and Orthogonalized Covariance Selection – Linear Discriminant Analysis
por: Marzetti, Emanuele, et al.
Publicado: (2020)

Circulating extracellular vesicles: friends and foes in neurodegeneration
por: Picca, Anna, et al.
Publicado: (2021)

Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration
por: Picca, Anna, et al.
Publicado: (2020)

Inter-Organelle Membrane Contact Sites and Mitochondrial Quality Control during Aging: A Geroscience View
por: Picca, Anna, et al.
Publicado: (2020)

Subacute onset dystonia in a woman affected by Parkinson’s disease following SARS-COV-2 infection
por: Lo Monaco, Maria Rita, et al.
Publicado: (2020)

Biomarkers of Physical Frailty and Sarcopenia: Coming up to the Place?
por: Picca, Anna, et al.
Publicado: (2020)

Plasma Therapies and Parabiosis in the COVID-19 Era
por: Calvani, Riccardo, et al.
Publicado: (2020)

STN-DBS does not increase the risk of sialorrhea in patients with advanced Parkinson’s disease
por: Bove, Francesco, et al.
Publicado: (2022)

The “develOpment of metabolic and functional markers of Dementia IN Older people” (ODINO) Study: Rationale, Design and Methods
por: Picca, Anna, et al.
Publicado: (2020)

Extracellular Vesicles and Pancreatic Cancer: Insights on the Roles of miRNA, lncRNA, and Protein Cargos in Cancer Progression
por: Romano, Roberta, et al.
Publicado: (2021)

Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets
por: Picca, Anna, et al.
Publicado: (2017)

Impact of habitual physical activity and type of exercise on physical performance across ages in community-living people
por: Landi, Francesco, et al.
Publicado: (2018)

Circulating Mitochondrial DNA and Inter-Organelle Contact Sites in Aging and Associated Conditions
por: Picca, Anna, et al.
Publicado: (2022)

Untangling the relationship between fat distribution, nutritional status and Parkinson’s disease severity
por: Pisciotta, Maria S., et al.
Publicado: (2019)

Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia
por: Picca, Anna, et al.
Publicado: (2018)

Cell Death and Inflammation: The Role of Mitochondria in Health and Disease
por: Picca, Anna, et al.
Publicado: (2021)

Protein Intake and Cognitive Function in Older Adults: A Systematic Review and Meta-Analysis
por: Coelho-Júnior, Hélio José, et al.
Publicado: (2021)

Anorexia of Aging: Metabolic Changes and Biomarker Discovery
por: Picca, Anna, et al.
Publicado: (2022)

Synergistic Effect of Mitochondrial and Lysosomal Dysfunction in Parkinson’s Disease
por: Guerra, Flora, et al.
Publicado: (2019)

Association between Dietary Habits and Physical Function in Brazilian and Italian Older Women
por: Coelho-Junior, Hélio J., et al.
Publicado: (2020)

Protein-Related Dietary Parameters and Frailty Status in Older Community-Dwellers across Different Frailty Instruments
por: Coelho-Júnior, Hélio J., et al.
Publicado: (2020)

Operationalization of the physical frailty & sarcopenia syndrome: rationale and clinical implementation
por: Marzetti, E., et al.
Publicado: (2016)

An educational case series of Parkinson's disease during the COVID-19 pandemic
por: Lo Monaco, M.R., et al.
Publicado: (2021)

Protein Intake and Frailty in Older Adults: A Systematic Review and Meta-Analysis of Observational Studies
por: Coelho-Junior, Hélio José, et al.
Publicado: (2022)

Circulating Inflammatory, Mitochondrial Dysfunction, and Senescence-Related Markers in Older Adults with Physical Frailty and Sarcopenia: A BIOSPHERE Exploratory Study
por: Picca, Anna, et al.
Publicado: (2022)

Reply to Grant, W.B. Comment on “Coelho-Junior et al. Protein Intake and Frailty in Older Adults: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients 2022, 14, 2767”
por: Coelho-Junior, Hélio José, et al.
Publicado: (2022)

Engagement in Aerobic Exercise Is Associated with a Reduced Prevalence of Sarcopenia and Severe Sarcopenia in Italian Older Adults
por: Coelho-Júnior, Hélio José, et al.
Publicado: (2023)

Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome
por: Piano, Carla, et al.
Publicado: (2021)

The Rationale for Exercise in the Management of Pain in Parkinson’s Disease
por: Allen, Natalie E., et al.
Publicado: (2015)

Impact of physical function impairment and multimorbidity on mortality among community-living older persons with sarcopaenia: results from the ilSIRENTE prospective cohort study
por: Landi, Francesco, et al.
Publicado: (2016)

Prevalence of dyslipidaemia and awareness of blood cholesterol levels among community-living people: results from the Longevity check-up 7+ (Lookup 7+) cross-sectional survey
por: Marzetti, Emanuele, et al.
Publicado: (2018)

COVID-19 Pandemic and Psychiatric Symptoms: The Impact on Parkinson's Disease in the Elderly
por: Janiri, Delfina, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_8codumfm98k7fv9c0nnctvq0q4