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Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been co...

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Detalles Bibliográficos
Autores principales: Mata-Rocha, Minerva, Rangel-López, Angelica, Jiménez-Hernández, Elva, Morales-Castillo, Blanca Angélica, González-Torres, Carolina, Gaytan-Cervantes, Javier, Álvarez-Olmos, Enrique, Núñez-Enríquez, Juan Carlos, Fajardo-Gutiérrez, Arturo, Martín-Trejo, Jorge Alfonso, Solís-Labastida, Karina Anastacia, Medina-Sansón, Aurora, Flores-Lujano, Janet, Sepúlveda-Robles, Omar Alejandro, Peñaloza-González, José Gabriel, Espinoza-Hernández, Laura Eugenia, Núñez-Villegas, Nora Nancy, Espinosa-Elizondo, Rosa Martha, Cortés-Herrera, Beatriz, Torres-Nava, José Refugio, Flores-Villegas, Luz Victoria, Merino-Pasaye, Laura Elizabeth, Bekker-Méndez, Vilma Carolina, Velázquez-Aviña, Martha Margarita, Pérez-Saldívar, María Luisa, Bautista-Martínez, Benito Alejandro, Amador-Sánchez, Raquel, González-Avila, Ana Itamar, Jiménez-Morales, Silvia, Duarte-Rodríguez, David Aldebarán, Santillán-Juárez, Jessica Denisse, García-Velázquez, Alejandra Jimena, Rosas-Vargas, Haydeé, Mejía-Aranguré, Juan Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566803/
https://www.ncbi.nlm.nih.gov/pubmed/31096545
http://dx.doi.org/10.3390/ijms20102394
Descripción
Sumario:Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been considered as important treatment targets in childhood acute lymphoblastic leukemia (ALL). The present research aimed at the identification and characterization of novel fusion genes with potential clinical implications in Mexican children with acute lymphoblastic leukemia. The RNA-sequencing approach was used. Four fusion genes not previously reported were identified: CREBBP-SRGAP2B, DNAH14-IKZF1, ETV6-SNUPN, ETV6-NUFIP1. Although a fusion gene is not sufficient to cause leukemia, it could be involved in the pathogenesis of the disease. Notably, these new translocations were found in genes encoding for hematopoietic transcription factors which are known to play an important role in leukemogenesis and disease prognosis such as IKZF1, CREBBP, and ETV6. In addition, they may have an impact on the prognosis of Mexican pediatric patients with ALL, with the potential to be included in the current risk stratification schemes or used as therapeutic targets.