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Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been co...

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Autores principales: Mata-Rocha, Minerva, Rangel-López, Angelica, Jiménez-Hernández, Elva, Morales-Castillo, Blanca Angélica, González-Torres, Carolina, Gaytan-Cervantes, Javier, Álvarez-Olmos, Enrique, Núñez-Enríquez, Juan Carlos, Fajardo-Gutiérrez, Arturo, Martín-Trejo, Jorge Alfonso, Solís-Labastida, Karina Anastacia, Medina-Sansón, Aurora, Flores-Lujano, Janet, Sepúlveda-Robles, Omar Alejandro, Peñaloza-González, José Gabriel, Espinoza-Hernández, Laura Eugenia, Núñez-Villegas, Nora Nancy, Espinosa-Elizondo, Rosa Martha, Cortés-Herrera, Beatriz, Torres-Nava, José Refugio, Flores-Villegas, Luz Victoria, Merino-Pasaye, Laura Elizabeth, Bekker-Méndez, Vilma Carolina, Velázquez-Aviña, Martha Margarita, Pérez-Saldívar, María Luisa, Bautista-Martínez, Benito Alejandro, Amador-Sánchez, Raquel, González-Avila, Ana Itamar, Jiménez-Morales, Silvia, Duarte-Rodríguez, David Aldebarán, Santillán-Juárez, Jessica Denisse, García-Velázquez, Alejandra Jimena, Rosas-Vargas, Haydeé, Mejía-Aranguré, Juan Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566803/
https://www.ncbi.nlm.nih.gov/pubmed/31096545
http://dx.doi.org/10.3390/ijms20102394
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author Mata-Rocha, Minerva
Rangel-López, Angelica
Jiménez-Hernández, Elva
Morales-Castillo, Blanca Angélica
González-Torres, Carolina
Gaytan-Cervantes, Javier
Álvarez-Olmos, Enrique
Núñez-Enríquez, Juan Carlos
Fajardo-Gutiérrez, Arturo
Martín-Trejo, Jorge Alfonso
Solís-Labastida, Karina Anastacia
Medina-Sansón, Aurora
Flores-Lujano, Janet
Sepúlveda-Robles, Omar Alejandro
Peñaloza-González, José Gabriel
Espinoza-Hernández, Laura Eugenia
Núñez-Villegas, Nora Nancy
Espinosa-Elizondo, Rosa Martha
Cortés-Herrera, Beatriz
Torres-Nava, José Refugio
Flores-Villegas, Luz Victoria
Merino-Pasaye, Laura Elizabeth
Bekker-Méndez, Vilma Carolina
Velázquez-Aviña, Martha Margarita
Pérez-Saldívar, María Luisa
Bautista-Martínez, Benito Alejandro
Amador-Sánchez, Raquel
González-Avila, Ana Itamar
Jiménez-Morales, Silvia
Duarte-Rodríguez, David Aldebarán
Santillán-Juárez, Jessica Denisse
García-Velázquez, Alejandra Jimena
Rosas-Vargas, Haydeé
Mejía-Aranguré, Juan Manuel
author_facet Mata-Rocha, Minerva
Rangel-López, Angelica
Jiménez-Hernández, Elva
Morales-Castillo, Blanca Angélica
González-Torres, Carolina
Gaytan-Cervantes, Javier
Álvarez-Olmos, Enrique
Núñez-Enríquez, Juan Carlos
Fajardo-Gutiérrez, Arturo
Martín-Trejo, Jorge Alfonso
Solís-Labastida, Karina Anastacia
Medina-Sansón, Aurora
Flores-Lujano, Janet
Sepúlveda-Robles, Omar Alejandro
Peñaloza-González, José Gabriel
Espinoza-Hernández, Laura Eugenia
Núñez-Villegas, Nora Nancy
Espinosa-Elizondo, Rosa Martha
Cortés-Herrera, Beatriz
Torres-Nava, José Refugio
Flores-Villegas, Luz Victoria
Merino-Pasaye, Laura Elizabeth
Bekker-Méndez, Vilma Carolina
Velázquez-Aviña, Martha Margarita
Pérez-Saldívar, María Luisa
Bautista-Martínez, Benito Alejandro
Amador-Sánchez, Raquel
González-Avila, Ana Itamar
Jiménez-Morales, Silvia
Duarte-Rodríguez, David Aldebarán
Santillán-Juárez, Jessica Denisse
García-Velázquez, Alejandra Jimena
Rosas-Vargas, Haydeé
Mejía-Aranguré, Juan Manuel
author_sort Mata-Rocha, Minerva
collection PubMed
description Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been considered as important treatment targets in childhood acute lymphoblastic leukemia (ALL). The present research aimed at the identification and characterization of novel fusion genes with potential clinical implications in Mexican children with acute lymphoblastic leukemia. The RNA-sequencing approach was used. Four fusion genes not previously reported were identified: CREBBP-SRGAP2B, DNAH14-IKZF1, ETV6-SNUPN, ETV6-NUFIP1. Although a fusion gene is not sufficient to cause leukemia, it could be involved in the pathogenesis of the disease. Notably, these new translocations were found in genes encoding for hematopoietic transcription factors which are known to play an important role in leukemogenesis and disease prognosis such as IKZF1, CREBBP, and ETV6. In addition, they may have an impact on the prognosis of Mexican pediatric patients with ALL, with the potential to be included in the current risk stratification schemes or used as therapeutic targets.
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spelling pubmed-65668032019-06-17 Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia Mata-Rocha, Minerva Rangel-López, Angelica Jiménez-Hernández, Elva Morales-Castillo, Blanca Angélica González-Torres, Carolina Gaytan-Cervantes, Javier Álvarez-Olmos, Enrique Núñez-Enríquez, Juan Carlos Fajardo-Gutiérrez, Arturo Martín-Trejo, Jorge Alfonso Solís-Labastida, Karina Anastacia Medina-Sansón, Aurora Flores-Lujano, Janet Sepúlveda-Robles, Omar Alejandro Peñaloza-González, José Gabriel Espinoza-Hernández, Laura Eugenia Núñez-Villegas, Nora Nancy Espinosa-Elizondo, Rosa Martha Cortés-Herrera, Beatriz Torres-Nava, José Refugio Flores-Villegas, Luz Victoria Merino-Pasaye, Laura Elizabeth Bekker-Méndez, Vilma Carolina Velázquez-Aviña, Martha Margarita Pérez-Saldívar, María Luisa Bautista-Martínez, Benito Alejandro Amador-Sánchez, Raquel González-Avila, Ana Itamar Jiménez-Morales, Silvia Duarte-Rodríguez, David Aldebarán Santillán-Juárez, Jessica Denisse García-Velázquez, Alejandra Jimena Rosas-Vargas, Haydeé Mejía-Aranguré, Juan Manuel Int J Mol Sci Article Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been considered as important treatment targets in childhood acute lymphoblastic leukemia (ALL). The present research aimed at the identification and characterization of novel fusion genes with potential clinical implications in Mexican children with acute lymphoblastic leukemia. The RNA-sequencing approach was used. Four fusion genes not previously reported were identified: CREBBP-SRGAP2B, DNAH14-IKZF1, ETV6-SNUPN, ETV6-NUFIP1. Although a fusion gene is not sufficient to cause leukemia, it could be involved in the pathogenesis of the disease. Notably, these new translocations were found in genes encoding for hematopoietic transcription factors which are known to play an important role in leukemogenesis and disease prognosis such as IKZF1, CREBBP, and ETV6. In addition, they may have an impact on the prognosis of Mexican pediatric patients with ALL, with the potential to be included in the current risk stratification schemes or used as therapeutic targets. MDPI 2019-05-15 /pmc/articles/PMC6566803/ /pubmed/31096545 http://dx.doi.org/10.3390/ijms20102394 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mata-Rocha, Minerva
Rangel-López, Angelica
Jiménez-Hernández, Elva
Morales-Castillo, Blanca Angélica
González-Torres, Carolina
Gaytan-Cervantes, Javier
Álvarez-Olmos, Enrique
Núñez-Enríquez, Juan Carlos
Fajardo-Gutiérrez, Arturo
Martín-Trejo, Jorge Alfonso
Solís-Labastida, Karina Anastacia
Medina-Sansón, Aurora
Flores-Lujano, Janet
Sepúlveda-Robles, Omar Alejandro
Peñaloza-González, José Gabriel
Espinoza-Hernández, Laura Eugenia
Núñez-Villegas, Nora Nancy
Espinosa-Elizondo, Rosa Martha
Cortés-Herrera, Beatriz
Torres-Nava, José Refugio
Flores-Villegas, Luz Victoria
Merino-Pasaye, Laura Elizabeth
Bekker-Méndez, Vilma Carolina
Velázquez-Aviña, Martha Margarita
Pérez-Saldívar, María Luisa
Bautista-Martínez, Benito Alejandro
Amador-Sánchez, Raquel
González-Avila, Ana Itamar
Jiménez-Morales, Silvia
Duarte-Rodríguez, David Aldebarán
Santillán-Juárez, Jessica Denisse
García-Velázquez, Alejandra Jimena
Rosas-Vargas, Haydeé
Mejía-Aranguré, Juan Manuel
Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia
title Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia
title_full Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia
title_fullStr Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia
title_full_unstemmed Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia
title_short Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia
title_sort identification and characterization of novel fusion genes with potential clinical applications in mexican children with acute lymphoblastic leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566803/
https://www.ncbi.nlm.nih.gov/pubmed/31096545
http://dx.doi.org/10.3390/ijms20102394
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