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Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been co...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566803/ https://www.ncbi.nlm.nih.gov/pubmed/31096545 http://dx.doi.org/10.3390/ijms20102394 |
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author | Mata-Rocha, Minerva Rangel-López, Angelica Jiménez-Hernández, Elva Morales-Castillo, Blanca Angélica González-Torres, Carolina Gaytan-Cervantes, Javier Álvarez-Olmos, Enrique Núñez-Enríquez, Juan Carlos Fajardo-Gutiérrez, Arturo Martín-Trejo, Jorge Alfonso Solís-Labastida, Karina Anastacia Medina-Sansón, Aurora Flores-Lujano, Janet Sepúlveda-Robles, Omar Alejandro Peñaloza-González, José Gabriel Espinoza-Hernández, Laura Eugenia Núñez-Villegas, Nora Nancy Espinosa-Elizondo, Rosa Martha Cortés-Herrera, Beatriz Torres-Nava, José Refugio Flores-Villegas, Luz Victoria Merino-Pasaye, Laura Elizabeth Bekker-Méndez, Vilma Carolina Velázquez-Aviña, Martha Margarita Pérez-Saldívar, María Luisa Bautista-Martínez, Benito Alejandro Amador-Sánchez, Raquel González-Avila, Ana Itamar Jiménez-Morales, Silvia Duarte-Rodríguez, David Aldebarán Santillán-Juárez, Jessica Denisse García-Velázquez, Alejandra Jimena Rosas-Vargas, Haydeé Mejía-Aranguré, Juan Manuel |
author_facet | Mata-Rocha, Minerva Rangel-López, Angelica Jiménez-Hernández, Elva Morales-Castillo, Blanca Angélica González-Torres, Carolina Gaytan-Cervantes, Javier Álvarez-Olmos, Enrique Núñez-Enríquez, Juan Carlos Fajardo-Gutiérrez, Arturo Martín-Trejo, Jorge Alfonso Solís-Labastida, Karina Anastacia Medina-Sansón, Aurora Flores-Lujano, Janet Sepúlveda-Robles, Omar Alejandro Peñaloza-González, José Gabriel Espinoza-Hernández, Laura Eugenia Núñez-Villegas, Nora Nancy Espinosa-Elizondo, Rosa Martha Cortés-Herrera, Beatriz Torres-Nava, José Refugio Flores-Villegas, Luz Victoria Merino-Pasaye, Laura Elizabeth Bekker-Méndez, Vilma Carolina Velázquez-Aviña, Martha Margarita Pérez-Saldívar, María Luisa Bautista-Martínez, Benito Alejandro Amador-Sánchez, Raquel González-Avila, Ana Itamar Jiménez-Morales, Silvia Duarte-Rodríguez, David Aldebarán Santillán-Juárez, Jessica Denisse García-Velázquez, Alejandra Jimena Rosas-Vargas, Haydeé Mejía-Aranguré, Juan Manuel |
author_sort | Mata-Rocha, Minerva |
collection | PubMed |
description | Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been considered as important treatment targets in childhood acute lymphoblastic leukemia (ALL). The present research aimed at the identification and characterization of novel fusion genes with potential clinical implications in Mexican children with acute lymphoblastic leukemia. The RNA-sequencing approach was used. Four fusion genes not previously reported were identified: CREBBP-SRGAP2B, DNAH14-IKZF1, ETV6-SNUPN, ETV6-NUFIP1. Although a fusion gene is not sufficient to cause leukemia, it could be involved in the pathogenesis of the disease. Notably, these new translocations were found in genes encoding for hematopoietic transcription factors which are known to play an important role in leukemogenesis and disease prognosis such as IKZF1, CREBBP, and ETV6. In addition, they may have an impact on the prognosis of Mexican pediatric patients with ALL, with the potential to be included in the current risk stratification schemes or used as therapeutic targets. |
format | Online Article Text |
id | pubmed-6566803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65668032019-06-17 Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia Mata-Rocha, Minerva Rangel-López, Angelica Jiménez-Hernández, Elva Morales-Castillo, Blanca Angélica González-Torres, Carolina Gaytan-Cervantes, Javier Álvarez-Olmos, Enrique Núñez-Enríquez, Juan Carlos Fajardo-Gutiérrez, Arturo Martín-Trejo, Jorge Alfonso Solís-Labastida, Karina Anastacia Medina-Sansón, Aurora Flores-Lujano, Janet Sepúlveda-Robles, Omar Alejandro Peñaloza-González, José Gabriel Espinoza-Hernández, Laura Eugenia Núñez-Villegas, Nora Nancy Espinosa-Elizondo, Rosa Martha Cortés-Herrera, Beatriz Torres-Nava, José Refugio Flores-Villegas, Luz Victoria Merino-Pasaye, Laura Elizabeth Bekker-Méndez, Vilma Carolina Velázquez-Aviña, Martha Margarita Pérez-Saldívar, María Luisa Bautista-Martínez, Benito Alejandro Amador-Sánchez, Raquel González-Avila, Ana Itamar Jiménez-Morales, Silvia Duarte-Rodríguez, David Aldebarán Santillán-Juárez, Jessica Denisse García-Velázquez, Alejandra Jimena Rosas-Vargas, Haydeé Mejía-Aranguré, Juan Manuel Int J Mol Sci Article Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been considered as important treatment targets in childhood acute lymphoblastic leukemia (ALL). The present research aimed at the identification and characterization of novel fusion genes with potential clinical implications in Mexican children with acute lymphoblastic leukemia. The RNA-sequencing approach was used. Four fusion genes not previously reported were identified: CREBBP-SRGAP2B, DNAH14-IKZF1, ETV6-SNUPN, ETV6-NUFIP1. Although a fusion gene is not sufficient to cause leukemia, it could be involved in the pathogenesis of the disease. Notably, these new translocations were found in genes encoding for hematopoietic transcription factors which are known to play an important role in leukemogenesis and disease prognosis such as IKZF1, CREBBP, and ETV6. In addition, they may have an impact on the prognosis of Mexican pediatric patients with ALL, with the potential to be included in the current risk stratification schemes or used as therapeutic targets. MDPI 2019-05-15 /pmc/articles/PMC6566803/ /pubmed/31096545 http://dx.doi.org/10.3390/ijms20102394 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mata-Rocha, Minerva Rangel-López, Angelica Jiménez-Hernández, Elva Morales-Castillo, Blanca Angélica González-Torres, Carolina Gaytan-Cervantes, Javier Álvarez-Olmos, Enrique Núñez-Enríquez, Juan Carlos Fajardo-Gutiérrez, Arturo Martín-Trejo, Jorge Alfonso Solís-Labastida, Karina Anastacia Medina-Sansón, Aurora Flores-Lujano, Janet Sepúlveda-Robles, Omar Alejandro Peñaloza-González, José Gabriel Espinoza-Hernández, Laura Eugenia Núñez-Villegas, Nora Nancy Espinosa-Elizondo, Rosa Martha Cortés-Herrera, Beatriz Torres-Nava, José Refugio Flores-Villegas, Luz Victoria Merino-Pasaye, Laura Elizabeth Bekker-Méndez, Vilma Carolina Velázquez-Aviña, Martha Margarita Pérez-Saldívar, María Luisa Bautista-Martínez, Benito Alejandro Amador-Sánchez, Raquel González-Avila, Ana Itamar Jiménez-Morales, Silvia Duarte-Rodríguez, David Aldebarán Santillán-Juárez, Jessica Denisse García-Velázquez, Alejandra Jimena Rosas-Vargas, Haydeé Mejía-Aranguré, Juan Manuel Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia |
title | Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia |
title_full | Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia |
title_fullStr | Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia |
title_full_unstemmed | Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia |
title_short | Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia |
title_sort | identification and characterization of novel fusion genes with potential clinical applications in mexican children with acute lymphoblastic leukemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566803/ https://www.ncbi.nlm.nih.gov/pubmed/31096545 http://dx.doi.org/10.3390/ijms20102394 |
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