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Association of Stress, Mental Health, and VEGFR-2 Gene Polymorphisms with Cardiometabolic Risk in Chinese Malaysian Adults

Gene-environment (G × E) interactions involving job stress and mental health on risk factors of cardiovascular disease (CVD) are minimally explored. This study examined the association and G × E interaction effects of vascular endothelial growth factor receptor-2 (VEGFR-2) gene polymorphisms (rs1870...

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Autores principales: Yap, Roseline W. K., Lin, Mei-Hua, Shidoji, Yoshihiro, Yap, Wai Sum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566873/
https://www.ncbi.nlm.nih.gov/pubmed/31121870
http://dx.doi.org/10.3390/nu11051140
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author Yap, Roseline W. K.
Lin, Mei-Hua
Shidoji, Yoshihiro
Yap, Wai Sum
author_facet Yap, Roseline W. K.
Lin, Mei-Hua
Shidoji, Yoshihiro
Yap, Wai Sum
author_sort Yap, Roseline W. K.
collection PubMed
description Gene-environment (G × E) interactions involving job stress and mental health on risk factors of cardiovascular disease (CVD) are minimally explored. This study examined the association and G × E interaction effects of vascular endothelial growth factor receptor-2 (VEGFR-2) gene polymorphisms (rs1870377, rs2071559) on cardiometabolic risk in Chinese Malaysian adults. Questionnaires: Job Stress Scale (JSS); Depression, Anxiety, and Stress Scale (DASS-21); and Rhode Island Stress and Coping Inventory (RISCI) were used to measure job stress, mental health, and coping with perceived stress. Cardiometabolic risk parameters were evaluated in plasma and genotyping analysis was performed by real-time polymerase chain reaction. The subjects were 127 Chinese Malaysian adults. The allele frequencies for rs1870377 (A allele and T allele) and rs2071557 (A allele and T allele) polymorphisms were 0.48 and 0.52, and 0.37 and 0.63, respectively. Significant correlations include scores from JSS dimensions with blood glucose (BG) (p = 0.025–0.045), DASS-21 dimensions with blood pressure, BMI, and uric acid (p = 0.029–0.047), and RISCI with blood pressure and BG (p = 0.016–0.049). Significant G × E interactions were obtained for: rs1870377 with stress on total cholesterol (p = 0.035), low density lipoprotein cholesterol (p = 0.019), and apolipoprotein B100 (p = 0.004); and rs2071559 with anxiety on blood pressure (p = 0.006–0.045). The significant G × E interactions prompt actions for managing stress and anxiety for the prevention of CVD.
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spelling pubmed-65668732019-06-17 Association of Stress, Mental Health, and VEGFR-2 Gene Polymorphisms with Cardiometabolic Risk in Chinese Malaysian Adults Yap, Roseline W. K. Lin, Mei-Hua Shidoji, Yoshihiro Yap, Wai Sum Nutrients Article Gene-environment (G × E) interactions involving job stress and mental health on risk factors of cardiovascular disease (CVD) are minimally explored. This study examined the association and G × E interaction effects of vascular endothelial growth factor receptor-2 (VEGFR-2) gene polymorphisms (rs1870377, rs2071559) on cardiometabolic risk in Chinese Malaysian adults. Questionnaires: Job Stress Scale (JSS); Depression, Anxiety, and Stress Scale (DASS-21); and Rhode Island Stress and Coping Inventory (RISCI) were used to measure job stress, mental health, and coping with perceived stress. Cardiometabolic risk parameters were evaluated in plasma and genotyping analysis was performed by real-time polymerase chain reaction. The subjects were 127 Chinese Malaysian adults. The allele frequencies for rs1870377 (A allele and T allele) and rs2071557 (A allele and T allele) polymorphisms were 0.48 and 0.52, and 0.37 and 0.63, respectively. Significant correlations include scores from JSS dimensions with blood glucose (BG) (p = 0.025–0.045), DASS-21 dimensions with blood pressure, BMI, and uric acid (p = 0.029–0.047), and RISCI with blood pressure and BG (p = 0.016–0.049). Significant G × E interactions were obtained for: rs1870377 with stress on total cholesterol (p = 0.035), low density lipoprotein cholesterol (p = 0.019), and apolipoprotein B100 (p = 0.004); and rs2071559 with anxiety on blood pressure (p = 0.006–0.045). The significant G × E interactions prompt actions for managing stress and anxiety for the prevention of CVD. MDPI 2019-05-22 /pmc/articles/PMC6566873/ /pubmed/31121870 http://dx.doi.org/10.3390/nu11051140 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yap, Roseline W. K.
Lin, Mei-Hua
Shidoji, Yoshihiro
Yap, Wai Sum
Association of Stress, Mental Health, and VEGFR-2 Gene Polymorphisms with Cardiometabolic Risk in Chinese Malaysian Adults
title Association of Stress, Mental Health, and VEGFR-2 Gene Polymorphisms with Cardiometabolic Risk in Chinese Malaysian Adults
title_full Association of Stress, Mental Health, and VEGFR-2 Gene Polymorphisms with Cardiometabolic Risk in Chinese Malaysian Adults
title_fullStr Association of Stress, Mental Health, and VEGFR-2 Gene Polymorphisms with Cardiometabolic Risk in Chinese Malaysian Adults
title_full_unstemmed Association of Stress, Mental Health, and VEGFR-2 Gene Polymorphisms with Cardiometabolic Risk in Chinese Malaysian Adults
title_short Association of Stress, Mental Health, and VEGFR-2 Gene Polymorphisms with Cardiometabolic Risk in Chinese Malaysian Adults
title_sort association of stress, mental health, and vegfr-2 gene polymorphisms with cardiometabolic risk in chinese malaysian adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566873/
https://www.ncbi.nlm.nih.gov/pubmed/31121870
http://dx.doi.org/10.3390/nu11051140
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