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Biomimetic Collagen/Zn(2+)-Substituted Calcium Phosphate Composite Coatings on Titanium Substrates as Prospective Bioactive Layer for Implants: A Comparative Study Spin Coating vs. MAPLE

Synthesis of biomimetic materials for implants and prostheses is a hot topic in nanobiotechnology strategies. Today the major approach of orthopaedic implants in hard tissue engineering is represented by titanium implants. A comparative study of hybrid thin coatings deposition was performed by spin...

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Autores principales: Neacsu, Ionela Andreea, Arsenie, Laura Vasilica, Trusca, Roxana, Ardelean, Ioana Lavinia, Mihailescu, Natalia, Mihailescu, Ion Nicolae, Ristoscu, Carmen, Bleotu, Coralia, Ficai, Anton, Andronescu, Ecaterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566990/
https://www.ncbi.nlm.nih.gov/pubmed/31058851
http://dx.doi.org/10.3390/nano9050692
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author Neacsu, Ionela Andreea
Arsenie, Laura Vasilica
Trusca, Roxana
Ardelean, Ioana Lavinia
Mihailescu, Natalia
Mihailescu, Ion Nicolae
Ristoscu, Carmen
Bleotu, Coralia
Ficai, Anton
Andronescu, Ecaterina
author_facet Neacsu, Ionela Andreea
Arsenie, Laura Vasilica
Trusca, Roxana
Ardelean, Ioana Lavinia
Mihailescu, Natalia
Mihailescu, Ion Nicolae
Ristoscu, Carmen
Bleotu, Coralia
Ficai, Anton
Andronescu, Ecaterina
author_sort Neacsu, Ionela Andreea
collection PubMed
description Synthesis of biomimetic materials for implants and prostheses is a hot topic in nanobiotechnology strategies. Today the major approach of orthopaedic implants in hard tissue engineering is represented by titanium implants. A comparative study of hybrid thin coatings deposition was performed by spin coating and matrix-assisted pulsed laser evaporation (MAPLE) onto titanium substrates. The Collagen-calcium phosphate (Coll-CaPs) combination was selected as the best option to mimic natural bone tissue. To accelerate the mineralization process, Zn(2+) ions were inserted by substitution in CaPs. A superior thin film homogeneity was assessed by MAPLE, as shown by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) microscopy. A decrease of P-O and amide absorbance bands was observed as a consequence of different Zn(2+) amounts. A variety of structural modifications of the apatite layer are then generated, which influenced the confinement process towards the collagen template. The in-vitro Simulated Body Fluid (SBF) assay demonstrated the ability of Coll/Zn(2+)-CaPs coatings to stimulate the mineralization process as a result of synergic effects in the collagen-Zn(2+) substituted apatite. For both deposition methods, the formation of droplets associated to the growth of CaPs particulates inside the collagen matrix was visualized. This supports the prospective behavior of MAPLE biomimetic coatings to induce mineralization, as an essential step of fast implant integration with vivid tissues.
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spelling pubmed-65669902019-06-17 Biomimetic Collagen/Zn(2+)-Substituted Calcium Phosphate Composite Coatings on Titanium Substrates as Prospective Bioactive Layer for Implants: A Comparative Study Spin Coating vs. MAPLE Neacsu, Ionela Andreea Arsenie, Laura Vasilica Trusca, Roxana Ardelean, Ioana Lavinia Mihailescu, Natalia Mihailescu, Ion Nicolae Ristoscu, Carmen Bleotu, Coralia Ficai, Anton Andronescu, Ecaterina Nanomaterials (Basel) Article Synthesis of biomimetic materials for implants and prostheses is a hot topic in nanobiotechnology strategies. Today the major approach of orthopaedic implants in hard tissue engineering is represented by titanium implants. A comparative study of hybrid thin coatings deposition was performed by spin coating and matrix-assisted pulsed laser evaporation (MAPLE) onto titanium substrates. The Collagen-calcium phosphate (Coll-CaPs) combination was selected as the best option to mimic natural bone tissue. To accelerate the mineralization process, Zn(2+) ions were inserted by substitution in CaPs. A superior thin film homogeneity was assessed by MAPLE, as shown by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) microscopy. A decrease of P-O and amide absorbance bands was observed as a consequence of different Zn(2+) amounts. A variety of structural modifications of the apatite layer are then generated, which influenced the confinement process towards the collagen template. The in-vitro Simulated Body Fluid (SBF) assay demonstrated the ability of Coll/Zn(2+)-CaPs coatings to stimulate the mineralization process as a result of synergic effects in the collagen-Zn(2+) substituted apatite. For both deposition methods, the formation of droplets associated to the growth of CaPs particulates inside the collagen matrix was visualized. This supports the prospective behavior of MAPLE biomimetic coatings to induce mineralization, as an essential step of fast implant integration with vivid tissues. MDPI 2019-05-03 /pmc/articles/PMC6566990/ /pubmed/31058851 http://dx.doi.org/10.3390/nano9050692 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Neacsu, Ionela Andreea
Arsenie, Laura Vasilica
Trusca, Roxana
Ardelean, Ioana Lavinia
Mihailescu, Natalia
Mihailescu, Ion Nicolae
Ristoscu, Carmen
Bleotu, Coralia
Ficai, Anton
Andronescu, Ecaterina
Biomimetic Collagen/Zn(2+)-Substituted Calcium Phosphate Composite Coatings on Titanium Substrates as Prospective Bioactive Layer for Implants: A Comparative Study Spin Coating vs. MAPLE
title Biomimetic Collagen/Zn(2+)-Substituted Calcium Phosphate Composite Coatings on Titanium Substrates as Prospective Bioactive Layer for Implants: A Comparative Study Spin Coating vs. MAPLE
title_full Biomimetic Collagen/Zn(2+)-Substituted Calcium Phosphate Composite Coatings on Titanium Substrates as Prospective Bioactive Layer for Implants: A Comparative Study Spin Coating vs. MAPLE
title_fullStr Biomimetic Collagen/Zn(2+)-Substituted Calcium Phosphate Composite Coatings on Titanium Substrates as Prospective Bioactive Layer for Implants: A Comparative Study Spin Coating vs. MAPLE
title_full_unstemmed Biomimetic Collagen/Zn(2+)-Substituted Calcium Phosphate Composite Coatings on Titanium Substrates as Prospective Bioactive Layer for Implants: A Comparative Study Spin Coating vs. MAPLE
title_short Biomimetic Collagen/Zn(2+)-Substituted Calcium Phosphate Composite Coatings on Titanium Substrates as Prospective Bioactive Layer for Implants: A Comparative Study Spin Coating vs. MAPLE
title_sort biomimetic collagen/zn(2+)-substituted calcium phosphate composite coatings on titanium substrates as prospective bioactive layer for implants: a comparative study spin coating vs. maple
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566990/
https://www.ncbi.nlm.nih.gov/pubmed/31058851
http://dx.doi.org/10.3390/nano9050692
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