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Effect of Protein-Fortified Diet on Nitrogen Balance in Critically Ill Patients: Results from the OPINiB Trial
Nitrogen balance (NB) is considered a good marker of adequate protein intake and it has been suggested to be a good predictor of patients’ health outcomes. However, in literature, there is a lack of large randomized trials examining NB-guided protein intake in patients in intensive care units (ICUs)...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567073/ https://www.ncbi.nlm.nih.gov/pubmed/31035354 http://dx.doi.org/10.3390/nu11050972 |
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author | Danielis, Matteo Lorenzoni, Giulia Azzolina, Danila Iacobucci, Anna Trombini, Omar De Monte, Amato Gregori, Dario Beltrame, Fabio |
author_facet | Danielis, Matteo Lorenzoni, Giulia Azzolina, Danila Iacobucci, Anna Trombini, Omar De Monte, Amato Gregori, Dario Beltrame, Fabio |
author_sort | Danielis, Matteo |
collection | PubMed |
description | Nitrogen balance (NB) is considered a good marker of adequate protein intake and it has been suggested to be a good predictor of patients’ health outcomes. However, in literature, there is a lack of large randomized trials examining NB-guided protein intake in patients in intensive care units (ICUs). A randomized controlled trial enrolling patients admitted to ICU was done to compare changes in NB. Participants were randomized to a standard or protein-fortified diet (protein intake of 1.8 g/kg/day according to the guidelines of the Society of Critical Care Medicine and the American Society for Parenteral and Enteral Nutrition). The primary endpoint was represented by the NB on Day 1, 3, and study exit. Forty patients were enrolled in the study (19 in the protein-fortified group). The longitudinal analysis showed that, on Day 3, patients randomized to the protein-fortified diet were more likely (p < 0.001) to present better NB (at 3 days, patients in the protein-fortified diet were estimated to have a nitrate value of 5.22 g more than patients in the standard diet, 95% CI 3.86–6.58). The protein-fortified diet was found to be significantly and directly associated with changes in NB in critically ill patients admitted to ICU. |
format | Online Article Text |
id | pubmed-6567073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65670732019-06-17 Effect of Protein-Fortified Diet on Nitrogen Balance in Critically Ill Patients: Results from the OPINiB Trial Danielis, Matteo Lorenzoni, Giulia Azzolina, Danila Iacobucci, Anna Trombini, Omar De Monte, Amato Gregori, Dario Beltrame, Fabio Nutrients Article Nitrogen balance (NB) is considered a good marker of adequate protein intake and it has been suggested to be a good predictor of patients’ health outcomes. However, in literature, there is a lack of large randomized trials examining NB-guided protein intake in patients in intensive care units (ICUs). A randomized controlled trial enrolling patients admitted to ICU was done to compare changes in NB. Participants were randomized to a standard or protein-fortified diet (protein intake of 1.8 g/kg/day according to the guidelines of the Society of Critical Care Medicine and the American Society for Parenteral and Enteral Nutrition). The primary endpoint was represented by the NB on Day 1, 3, and study exit. Forty patients were enrolled in the study (19 in the protein-fortified group). The longitudinal analysis showed that, on Day 3, patients randomized to the protein-fortified diet were more likely (p < 0.001) to present better NB (at 3 days, patients in the protein-fortified diet were estimated to have a nitrate value of 5.22 g more than patients in the standard diet, 95% CI 3.86–6.58). The protein-fortified diet was found to be significantly and directly associated with changes in NB in critically ill patients admitted to ICU. MDPI 2019-04-28 /pmc/articles/PMC6567073/ /pubmed/31035354 http://dx.doi.org/10.3390/nu11050972 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Danielis, Matteo Lorenzoni, Giulia Azzolina, Danila Iacobucci, Anna Trombini, Omar De Monte, Amato Gregori, Dario Beltrame, Fabio Effect of Protein-Fortified Diet on Nitrogen Balance in Critically Ill Patients: Results from the OPINiB Trial |
title | Effect of Protein-Fortified Diet on Nitrogen Balance in Critically Ill Patients: Results from the OPINiB Trial |
title_full | Effect of Protein-Fortified Diet on Nitrogen Balance in Critically Ill Patients: Results from the OPINiB Trial |
title_fullStr | Effect of Protein-Fortified Diet on Nitrogen Balance in Critically Ill Patients: Results from the OPINiB Trial |
title_full_unstemmed | Effect of Protein-Fortified Diet on Nitrogen Balance in Critically Ill Patients: Results from the OPINiB Trial |
title_short | Effect of Protein-Fortified Diet on Nitrogen Balance in Critically Ill Patients: Results from the OPINiB Trial |
title_sort | effect of protein-fortified diet on nitrogen balance in critically ill patients: results from the opinib trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567073/ https://www.ncbi.nlm.nih.gov/pubmed/31035354 http://dx.doi.org/10.3390/nu11050972 |
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