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Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors
Immunostaining with specific antibodies has shown that innate amyloid beta (Aβ) is accumulated naturally in glioma tumors and nearby blood vessels in a mouse model of glioma. In immunofluorescence images, Aβ peptide coincides with glioma cells, and enzyme-linked immunosorbent assay (ELISA) have show...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567111/ https://www.ncbi.nlm.nih.gov/pubmed/31137462 http://dx.doi.org/10.3390/ijms20102482 |
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author | Kucheryavykh, Lilia Y. Ortiz-Rivera, Jescelica Kucheryavykh, Yuriy V. Zayas-Santiago, Astrid Diaz-Garcia, Amanda Inyushin, Mikhail Y. |
author_facet | Kucheryavykh, Lilia Y. Ortiz-Rivera, Jescelica Kucheryavykh, Yuriy V. Zayas-Santiago, Astrid Diaz-Garcia, Amanda Inyushin, Mikhail Y. |
author_sort | Kucheryavykh, Lilia Y. |
collection | PubMed |
description | Immunostaining with specific antibodies has shown that innate amyloid beta (Aβ) is accumulated naturally in glioma tumors and nearby blood vessels in a mouse model of glioma. In immunofluorescence images, Aβ peptide coincides with glioma cells, and enzyme-linked immunosorbent assay (ELISA) have shown that Aβ peptide is enriched in the membrane protein fraction of tumor cells. ELISAs have also confirmed that the Aβ(1–40) peptide is enriched in glioma tumor areas relative to healthy brain areas. Thioflavin staining revealed that at least some amyloid is present in glioma tumors in aggregated forms. We may suggest that the presence of aggregated amyloid in glioma tumors together with the presence of Aβ immunofluorescence coinciding with glioma cells and the nearby vasculature imply that the source of Aβ peptides in glioma can be systemic Aβ from blood vessels, but this question remains unresolved and needs additional studies. |
format | Online Article Text |
id | pubmed-6567111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65671112019-06-17 Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors Kucheryavykh, Lilia Y. Ortiz-Rivera, Jescelica Kucheryavykh, Yuriy V. Zayas-Santiago, Astrid Diaz-Garcia, Amanda Inyushin, Mikhail Y. Int J Mol Sci Article Immunostaining with specific antibodies has shown that innate amyloid beta (Aβ) is accumulated naturally in glioma tumors and nearby blood vessels in a mouse model of glioma. In immunofluorescence images, Aβ peptide coincides with glioma cells, and enzyme-linked immunosorbent assay (ELISA) have shown that Aβ peptide is enriched in the membrane protein fraction of tumor cells. ELISAs have also confirmed that the Aβ(1–40) peptide is enriched in glioma tumor areas relative to healthy brain areas. Thioflavin staining revealed that at least some amyloid is present in glioma tumors in aggregated forms. We may suggest that the presence of aggregated amyloid in glioma tumors together with the presence of Aβ immunofluorescence coinciding with glioma cells and the nearby vasculature imply that the source of Aβ peptides in glioma can be systemic Aβ from blood vessels, but this question remains unresolved and needs additional studies. MDPI 2019-05-20 /pmc/articles/PMC6567111/ /pubmed/31137462 http://dx.doi.org/10.3390/ijms20102482 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kucheryavykh, Lilia Y. Ortiz-Rivera, Jescelica Kucheryavykh, Yuriy V. Zayas-Santiago, Astrid Diaz-Garcia, Amanda Inyushin, Mikhail Y. Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors |
title | Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors |
title_full | Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors |
title_fullStr | Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors |
title_full_unstemmed | Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors |
title_short | Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors |
title_sort | accumulation of innate amyloid beta peptide in glioblastoma tumors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567111/ https://www.ncbi.nlm.nih.gov/pubmed/31137462 http://dx.doi.org/10.3390/ijms20102482 |
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