Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC

The L-type calcium channel blocker fendiline has been shown to interfere with Ras-dependent signaling in K-Ras mutant cancer cells. Earlier studies from our lab had shown that treatment of pancreatic cancer cells with fendiline causes significant cytotoxicity and interferes with proliferation, survi...

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Detalles Bibliográficos
Autores principales: Alhothali, Marwa, Mathew, Mevin, Iyer, Geeta, Lawrence, Harshani R., Yang, Shengyu, Chellappan, Srikumar, Padmanabhan, Jaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567171/
https://www.ncbi.nlm.nih.gov/pubmed/31100813
http://dx.doi.org/10.3390/ijms20102423

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