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Influence of Hyperglycemia Associated with Enteral Nutrition on Mortality in Patients with Stroke

Objectives: To evaluate in patients admitted for stroke: (1) The frequency of hyperglycaemia associated with enteral nutrition (EN). (2) The risk of morbidity and mortality associated with the development of this type of hyperglycaemia. Methods: A longitudinal observational study was conducted in 11...

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Autores principales: López-Gómez, Juan José, Delgado-García, Esther, Coto-García, Cristina, Torres-Torres, Beatriz, Gómez-Hoyos, Emilia, Serrano-Valles, Cristina, Castro-Lozano, Ángeles, Arenillas-Lara, Juan F., de Luis-Román, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567189/
https://www.ncbi.nlm.nih.gov/pubmed/31052350
http://dx.doi.org/10.3390/nu11050996
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author López-Gómez, Juan José
Delgado-García, Esther
Coto-García, Cristina
Torres-Torres, Beatriz
Gómez-Hoyos, Emilia
Serrano-Valles, Cristina
Castro-Lozano, Ángeles
Arenillas-Lara, Juan F.
de Luis-Román, Daniel A.
author_facet López-Gómez, Juan José
Delgado-García, Esther
Coto-García, Cristina
Torres-Torres, Beatriz
Gómez-Hoyos, Emilia
Serrano-Valles, Cristina
Castro-Lozano, Ángeles
Arenillas-Lara, Juan F.
de Luis-Román, Daniel A.
author_sort López-Gómez, Juan José
collection PubMed
description Objectives: To evaluate in patients admitted for stroke: (1) The frequency of hyperglycaemia associated with enteral nutrition (EN). (2) The risk of morbidity and mortality associated with the development of this type of hyperglycaemia. Methods: A longitudinal observational study was conducted in 115 non-diabetic patients admitted for stroke with EN. Age, functional capacity (Rankin scale), and blood plasma glucose (BPG) were recorded. Hyperglycaemia was considered as: a value higher than 126 mg/dL before the EN and/or a value higher than 150 mg/dL after a week of enteral nutrition. According to this, three groups were differentiated: HyperES: Those who had hyperglycemia before the beginning of the EN (33% patients); NoHyper: those who did not have hyperglycemia before or after (47.8% patients); and HyperEN: Those who did not have hyperglycemia before but suffered it after the beginning of the EN (19.1% patients). Results: The age was 72.72 (15.32) years. A higher rate of mortality was observed in the HyperEN group 45.50%, than HyperES 15.80% or NoHyper: 10.90%). A lower recovery of the oral feeding was observed in those patients of the HyperEN group 27.30%, than HyperES: 42.10% or NoHyper: 61.80%). In the multivariate analysis adjusting for age, sex, and Rankin scale the development of hyperglycemia in those who did not have it at the beginning (HyperEN) was an independent risk factor for non-recovery of the oral feeding (OR: 4.21 (1.20–14.79), p = 0.02); and mortality adjusted for age, sex and Rankin scale (OR: 6.83 (1.76–26.47), p < 0.01). Conclusions: In non-diabetic patients admitted for stroke with EN, the development of hyperglycaemia in relation to enteral nutrition supposes an independent risk factor for mortality and for the non-recovery of the oral feeding.
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spelling pubmed-65671892019-06-17 Influence of Hyperglycemia Associated with Enteral Nutrition on Mortality in Patients with Stroke López-Gómez, Juan José Delgado-García, Esther Coto-García, Cristina Torres-Torres, Beatriz Gómez-Hoyos, Emilia Serrano-Valles, Cristina Castro-Lozano, Ángeles Arenillas-Lara, Juan F. de Luis-Román, Daniel A. Nutrients Article Objectives: To evaluate in patients admitted for stroke: (1) The frequency of hyperglycaemia associated with enteral nutrition (EN). (2) The risk of morbidity and mortality associated with the development of this type of hyperglycaemia. Methods: A longitudinal observational study was conducted in 115 non-diabetic patients admitted for stroke with EN. Age, functional capacity (Rankin scale), and blood plasma glucose (BPG) were recorded. Hyperglycaemia was considered as: a value higher than 126 mg/dL before the EN and/or a value higher than 150 mg/dL after a week of enteral nutrition. According to this, three groups were differentiated: HyperES: Those who had hyperglycemia before the beginning of the EN (33% patients); NoHyper: those who did not have hyperglycemia before or after (47.8% patients); and HyperEN: Those who did not have hyperglycemia before but suffered it after the beginning of the EN (19.1% patients). Results: The age was 72.72 (15.32) years. A higher rate of mortality was observed in the HyperEN group 45.50%, than HyperES 15.80% or NoHyper: 10.90%). A lower recovery of the oral feeding was observed in those patients of the HyperEN group 27.30%, than HyperES: 42.10% or NoHyper: 61.80%). In the multivariate analysis adjusting for age, sex, and Rankin scale the development of hyperglycemia in those who did not have it at the beginning (HyperEN) was an independent risk factor for non-recovery of the oral feeding (OR: 4.21 (1.20–14.79), p = 0.02); and mortality adjusted for age, sex and Rankin scale (OR: 6.83 (1.76–26.47), p < 0.01). Conclusions: In non-diabetic patients admitted for stroke with EN, the development of hyperglycaemia in relation to enteral nutrition supposes an independent risk factor for mortality and for the non-recovery of the oral feeding. MDPI 2019-04-30 /pmc/articles/PMC6567189/ /pubmed/31052350 http://dx.doi.org/10.3390/nu11050996 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
López-Gómez, Juan José
Delgado-García, Esther
Coto-García, Cristina
Torres-Torres, Beatriz
Gómez-Hoyos, Emilia
Serrano-Valles, Cristina
Castro-Lozano, Ángeles
Arenillas-Lara, Juan F.
de Luis-Román, Daniel A.
Influence of Hyperglycemia Associated with Enteral Nutrition on Mortality in Patients with Stroke
title Influence of Hyperglycemia Associated with Enteral Nutrition on Mortality in Patients with Stroke
title_full Influence of Hyperglycemia Associated with Enteral Nutrition on Mortality in Patients with Stroke
title_fullStr Influence of Hyperglycemia Associated with Enteral Nutrition on Mortality in Patients with Stroke
title_full_unstemmed Influence of Hyperglycemia Associated with Enteral Nutrition on Mortality in Patients with Stroke
title_short Influence of Hyperglycemia Associated with Enteral Nutrition on Mortality in Patients with Stroke
title_sort influence of hyperglycemia associated with enteral nutrition on mortality in patients with stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567189/
https://www.ncbi.nlm.nih.gov/pubmed/31052350
http://dx.doi.org/10.3390/nu11050996
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