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The Resveratrol Rice DJ526 Callus Significantly Increases the Lifespan of Drosophila (Resveratrol Rice DJ526 Callus for Longevity)

Resveratrol has gained widespread scientific attention due to its ability to significantly extend the lifespan of yeast. However, research on the efficacy of resveratrol on lifespan extension has yielded mixed results in animal studies, making resveratrol a contentious subject. In our previous work,...

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Autores principales: Khan, Mousumee, Park, Soyeon, Kim, Hyeon-Jin, Lee, Kui-Jae, Kim, Dea Heon, Baek, So-Hyeon, Hong, Seong-Tshool
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567216/
https://www.ncbi.nlm.nih.gov/pubmed/31036789
http://dx.doi.org/10.3390/nu11050983
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author Khan, Mousumee
Park, Soyeon
Kim, Hyeon-Jin
Lee, Kui-Jae
Kim, Dea Heon
Baek, So-Hyeon
Hong, Seong-Tshool
author_facet Khan, Mousumee
Park, Soyeon
Kim, Hyeon-Jin
Lee, Kui-Jae
Kim, Dea Heon
Baek, So-Hyeon
Hong, Seong-Tshool
author_sort Khan, Mousumee
collection PubMed
description Resveratrol has gained widespread scientific attention due to its ability to significantly extend the lifespan of yeast. However, research on the efficacy of resveratrol on lifespan extension has yielded mixed results in animal studies, making resveratrol a contentious subject. In our previous work, we reported that transgenic resveratrol rice DJ526 showed unusual health benefits beyond expectations. In this work, we established a callus culture of resveratrol rice DJ526, which contains 180 times more resveratrol than the grain, and found that resveratrol rice callus significantly extended the median lifespan of Drosophila melanogaster by up to 50% compared to the control. The resveratrol rice callus also ameliorated age-dependent symptoms, including locomotive deterioration, body weight gain, eye degeneration, and neurodegeneration of D. melanogaster with age progression. Considering that resveratrol is the most preferred antiaging compound due to its superior safety and proven mechanism against many serious adult diseases, the outstanding efficacy of resveratrol on the longevity of wild-type animals could cast a light on the development of antiaging therapeutic agents.
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spelling pubmed-65672162019-06-17 The Resveratrol Rice DJ526 Callus Significantly Increases the Lifespan of Drosophila (Resveratrol Rice DJ526 Callus for Longevity) Khan, Mousumee Park, Soyeon Kim, Hyeon-Jin Lee, Kui-Jae Kim, Dea Heon Baek, So-Hyeon Hong, Seong-Tshool Nutrients Article Resveratrol has gained widespread scientific attention due to its ability to significantly extend the lifespan of yeast. However, research on the efficacy of resveratrol on lifespan extension has yielded mixed results in animal studies, making resveratrol a contentious subject. In our previous work, we reported that transgenic resveratrol rice DJ526 showed unusual health benefits beyond expectations. In this work, we established a callus culture of resveratrol rice DJ526, which contains 180 times more resveratrol than the grain, and found that resveratrol rice callus significantly extended the median lifespan of Drosophila melanogaster by up to 50% compared to the control. The resveratrol rice callus also ameliorated age-dependent symptoms, including locomotive deterioration, body weight gain, eye degeneration, and neurodegeneration of D. melanogaster with age progression. Considering that resveratrol is the most preferred antiaging compound due to its superior safety and proven mechanism against many serious adult diseases, the outstanding efficacy of resveratrol on the longevity of wild-type animals could cast a light on the development of antiaging therapeutic agents. MDPI 2019-04-29 /pmc/articles/PMC6567216/ /pubmed/31036789 http://dx.doi.org/10.3390/nu11050983 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khan, Mousumee
Park, Soyeon
Kim, Hyeon-Jin
Lee, Kui-Jae
Kim, Dea Heon
Baek, So-Hyeon
Hong, Seong-Tshool
The Resveratrol Rice DJ526 Callus Significantly Increases the Lifespan of Drosophila (Resveratrol Rice DJ526 Callus for Longevity)
title The Resveratrol Rice DJ526 Callus Significantly Increases the Lifespan of Drosophila (Resveratrol Rice DJ526 Callus for Longevity)
title_full The Resveratrol Rice DJ526 Callus Significantly Increases the Lifespan of Drosophila (Resveratrol Rice DJ526 Callus for Longevity)
title_fullStr The Resveratrol Rice DJ526 Callus Significantly Increases the Lifespan of Drosophila (Resveratrol Rice DJ526 Callus for Longevity)
title_full_unstemmed The Resveratrol Rice DJ526 Callus Significantly Increases the Lifespan of Drosophila (Resveratrol Rice DJ526 Callus for Longevity)
title_short The Resveratrol Rice DJ526 Callus Significantly Increases the Lifespan of Drosophila (Resveratrol Rice DJ526 Callus for Longevity)
title_sort resveratrol rice dj526 callus significantly increases the lifespan of drosophila (resveratrol rice dj526 callus for longevity)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567216/
https://www.ncbi.nlm.nih.gov/pubmed/31036789
http://dx.doi.org/10.3390/nu11050983
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