Cargando…
Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem
Background: Anti-Müllerian hormone (AMH) is considered to be one of the most significant indicators of women’s fertility. Many studies have shown that vitamin D may modify human reproductive functions; however, the results are conflicting. The composition of follicular fluid (FF) creates the biochem...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567253/ https://www.ncbi.nlm.nih.gov/pubmed/31083424 http://dx.doi.org/10.3390/nu11051053 |
_version_ | 1783427034312081408 |
---|---|
author | Bednarska-Czerwińska, Anna Olszak-Wąsik, Katarzyna Olejek, Anita Czerwiński, Michał Tukiendorf, Andrzej |
author_facet | Bednarska-Czerwińska, Anna Olszak-Wąsik, Katarzyna Olejek, Anita Czerwiński, Michał Tukiendorf, Andrzej |
author_sort | Bednarska-Czerwińska, Anna |
collection | PubMed |
description | Background: Anti-Müllerian hormone (AMH) is considered to be one of the most significant indicators of women’s fertility. Many studies have shown that vitamin D may modify human reproductive functions; however, the results are conflicting. The composition of follicular fluid (FF) creates the biochemical environment of the oocyte and affects its quality, which later determines the embryo quality. In this study, we aimed to revise with advanced statistical techniques the relationship between AMH and vitamin D in FF. Methods: The study was designed as a prospective single-center study in infertile patients with AMH ≥ 0.7 ng/mL who underwent controlled ovarian hyperstimulation for in vitro fertilization. AMH and vitamin D levels in FF were measured. Next, the standard and advanced statistical (including segmented regression) techniques were applied. Results: We observed a negative linear correlation between levels of AMH in serum and FF and total vitamin D concentrations up to approximately 30 ng/mL; with a statistically significant relationship in FF. Beyond that concentration, the trend was positive but statistically insignificant. Conclusions: As an existing “change-point problem” was noticed, we suggest segmentation in the relationship between vitamin D and AMH during infertility treatment. |
format | Online Article Text |
id | pubmed-6567253 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65672532019-06-17 Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem Bednarska-Czerwińska, Anna Olszak-Wąsik, Katarzyna Olejek, Anita Czerwiński, Michał Tukiendorf, Andrzej Nutrients Article Background: Anti-Müllerian hormone (AMH) is considered to be one of the most significant indicators of women’s fertility. Many studies have shown that vitamin D may modify human reproductive functions; however, the results are conflicting. The composition of follicular fluid (FF) creates the biochemical environment of the oocyte and affects its quality, which later determines the embryo quality. In this study, we aimed to revise with advanced statistical techniques the relationship between AMH and vitamin D in FF. Methods: The study was designed as a prospective single-center study in infertile patients with AMH ≥ 0.7 ng/mL who underwent controlled ovarian hyperstimulation for in vitro fertilization. AMH and vitamin D levels in FF were measured. Next, the standard and advanced statistical (including segmented regression) techniques were applied. Results: We observed a negative linear correlation between levels of AMH in serum and FF and total vitamin D concentrations up to approximately 30 ng/mL; with a statistically significant relationship in FF. Beyond that concentration, the trend was positive but statistically insignificant. Conclusions: As an existing “change-point problem” was noticed, we suggest segmentation in the relationship between vitamin D and AMH during infertility treatment. MDPI 2019-05-10 /pmc/articles/PMC6567253/ /pubmed/31083424 http://dx.doi.org/10.3390/nu11051053 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bednarska-Czerwińska, Anna Olszak-Wąsik, Katarzyna Olejek, Anita Czerwiński, Michał Tukiendorf, Andrzej Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem |
title | Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem |
title_full | Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem |
title_fullStr | Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem |
title_full_unstemmed | Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem |
title_short | Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem |
title_sort | vitamin d and anti-müllerian hormone levels in infertility treatment: the change-point problem |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567253/ https://www.ncbi.nlm.nih.gov/pubmed/31083424 http://dx.doi.org/10.3390/nu11051053 |
work_keys_str_mv | AT bednarskaczerwinskaanna vitamindandantimullerianhormonelevelsininfertilitytreatmentthechangepointproblem AT olszakwasikkatarzyna vitamindandantimullerianhormonelevelsininfertilitytreatmentthechangepointproblem AT olejekanita vitamindandantimullerianhormonelevelsininfertilitytreatmentthechangepointproblem AT czerwinskimichał vitamindandantimullerianhormonelevelsininfertilitytreatmentthechangepointproblem AT tukiendorfandrzej vitamindandantimullerianhormonelevelsininfertilitytreatmentthechangepointproblem |