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Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem

Background: Anti-Müllerian hormone (AMH) is considered to be one of the most significant indicators of women’s fertility. Many studies have shown that vitamin D may modify human reproductive functions; however, the results are conflicting. The composition of follicular fluid (FF) creates the biochem...

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Autores principales: Bednarska-Czerwińska, Anna, Olszak-Wąsik, Katarzyna, Olejek, Anita, Czerwiński, Michał, Tukiendorf, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567253/
https://www.ncbi.nlm.nih.gov/pubmed/31083424
http://dx.doi.org/10.3390/nu11051053
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author Bednarska-Czerwińska, Anna
Olszak-Wąsik, Katarzyna
Olejek, Anita
Czerwiński, Michał
Tukiendorf, Andrzej
author_facet Bednarska-Czerwińska, Anna
Olszak-Wąsik, Katarzyna
Olejek, Anita
Czerwiński, Michał
Tukiendorf, Andrzej
author_sort Bednarska-Czerwińska, Anna
collection PubMed
description Background: Anti-Müllerian hormone (AMH) is considered to be one of the most significant indicators of women’s fertility. Many studies have shown that vitamin D may modify human reproductive functions; however, the results are conflicting. The composition of follicular fluid (FF) creates the biochemical environment of the oocyte and affects its quality, which later determines the embryo quality. In this study, we aimed to revise with advanced statistical techniques the relationship between AMH and vitamin D in FF. Methods: The study was designed as a prospective single-center study in infertile patients with AMH ≥ 0.7 ng/mL who underwent controlled ovarian hyperstimulation for in vitro fertilization. AMH and vitamin D levels in FF were measured. Next, the standard and advanced statistical (including segmented regression) techniques were applied. Results: We observed a negative linear correlation between levels of AMH in serum and FF and total vitamin D concentrations up to approximately 30 ng/mL; with a statistically significant relationship in FF. Beyond that concentration, the trend was positive but statistically insignificant. Conclusions: As an existing “change-point problem” was noticed, we suggest segmentation in the relationship between vitamin D and AMH during infertility treatment.
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spelling pubmed-65672532019-06-17 Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem Bednarska-Czerwińska, Anna Olszak-Wąsik, Katarzyna Olejek, Anita Czerwiński, Michał Tukiendorf, Andrzej Nutrients Article Background: Anti-Müllerian hormone (AMH) is considered to be one of the most significant indicators of women’s fertility. Many studies have shown that vitamin D may modify human reproductive functions; however, the results are conflicting. The composition of follicular fluid (FF) creates the biochemical environment of the oocyte and affects its quality, which later determines the embryo quality. In this study, we aimed to revise with advanced statistical techniques the relationship between AMH and vitamin D in FF. Methods: The study was designed as a prospective single-center study in infertile patients with AMH ≥ 0.7 ng/mL who underwent controlled ovarian hyperstimulation for in vitro fertilization. AMH and vitamin D levels in FF were measured. Next, the standard and advanced statistical (including segmented regression) techniques were applied. Results: We observed a negative linear correlation between levels of AMH in serum and FF and total vitamin D concentrations up to approximately 30 ng/mL; with a statistically significant relationship in FF. Beyond that concentration, the trend was positive but statistically insignificant. Conclusions: As an existing “change-point problem” was noticed, we suggest segmentation in the relationship between vitamin D and AMH during infertility treatment. MDPI 2019-05-10 /pmc/articles/PMC6567253/ /pubmed/31083424 http://dx.doi.org/10.3390/nu11051053 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bednarska-Czerwińska, Anna
Olszak-Wąsik, Katarzyna
Olejek, Anita
Czerwiński, Michał
Tukiendorf, Andrzej
Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem
title Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem
title_full Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem
title_fullStr Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem
title_full_unstemmed Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem
title_short Vitamin D and Anti-Müllerian Hormone Levels in Infertility Treatment: The Change-Point Problem
title_sort vitamin d and anti-müllerian hormone levels in infertility treatment: the change-point problem
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567253/
https://www.ncbi.nlm.nih.gov/pubmed/31083424
http://dx.doi.org/10.3390/nu11051053
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