PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8(+) T lymphocytes

BACKGROUND: Binding of the programmed death-1 (PD-1) receptor to its ligands (PD-L1/2) transduces inhibitory signals that promote exhaustion of activated T cells. Blockade of the PD-1 pathway is widely used for cancer treatment, yet the inhibitory signals transduced by PD-1 in T cells remain elusive...

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Detalles Bibliográficos
Autores principales: Ogando, Jesús, Sáez, María Eugenia, Santos, Javier, Nuevo-Tapioles, Cristina, Gut, Marta, Esteve-Codina, Anna, Heath, Simon, González-Pérez, Antonio, Cuezva, José M., Lacalle, Rosa Ana, Mañes, Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567413/
https://www.ncbi.nlm.nih.gov/pubmed/31196176
http://dx.doi.org/10.1186/s40425-019-0628-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567413/
https://www.ncbi.nlm.nih.gov/pubmed/31196176
http://dx.doi.org/10.1186/s40425-019-0628-7

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