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The phage T4 DNA ligase in vivo improves the survival-coupled bacterial mutagenesis
BACKGROUND: Microbial mutagenesis is an important avenue to acquire microbial strains with desirable traits for industry application. However, mutagens either chemical or physical used often leads narrow library pool due to high lethal rate. The T4 DNA ligase is one of the most widely utilized enzym...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567493/ https://www.ncbi.nlm.nih.gov/pubmed/31196093 http://dx.doi.org/10.1186/s12934-019-1160-7 |