Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a stroma-rich carcinoma, and pancreatic stellate cells (PSCs) are a major component of this dense stroma. PSCs play significant roles in metastatic progression and chemoresistance through cross-talk with cancer cells. Preclinical in vitro tumor...

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Detalles Bibliográficos
Autores principales: Hwang, Hyun Ju, Oh, Min-Suk, Lee, Dong Woo, Kuh, Hyo-Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567511/
https://www.ncbi.nlm.nih.gov/pubmed/31200779
http://dx.doi.org/10.1186/s13046-019-1225-9

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