Cargando…

Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFNγ receptor signaling

BACKGROUND: T-cell mediated immunotherapy brought clinical success for many cancer patients. Nonetheless, downregulation of MHC class I antigen presentation, frequently occurring in solid cancers, limits the efficacy of these therapies. Unraveling the mechanisms underlying this type of immune escape...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marijt, Koen A., Sluijter, Marjolein, Blijleven, Laura, Tolmeijer, Sofie H., Scheeren, Ferenc A., van der Burg, Sjoerd H., van Hall, Thorbald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567539/ https://www.ncbi.nlm.nih.gov/pubmed/31196219 http://dx.doi.org/10.1186/s40425-019-0627-8

Ejemplares similares

Cross-presentation of a TAP-independent signal peptide induces CD8 T immunity to escaped cancers but necessitates anchor replacement
por: Marijt, Koen A., et al.
Publicado: (2021)

T cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy
por: Doorduijn, Elien M., et al.
Publicado: (2017)

TEIPP peptides: exploration of unTAPped cancer antigens
por: Marijt, Koen A., et al.
Publicado: (2019)

Identification of non-mutated neoantigens presented by TAP-deficient tumors
por: Marijt, Koen A., et al.
Publicado: (2018)

Intertumoral Differences Dictate the Outcome of TGF-β Blockade on the Efficacy of Viro-Immunotherapy
por: Groeneveldt, Christianne, et al.
Publicado: (2023)

T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1(b) with TAP-Independent Peptides Are Semi-Invariant Lymphocytes
por: Doorduijn, Elien M., et al.
Publicado: (2018)

Human Papillomavirus Downregulates the Expression of IFITM1 and RIPK3 to Escape from IFNγ- and TNFα-Mediated Antiproliferative Effects and Necroptosis
por: Ma, Wenbo, et al.
Publicado: (2016)

Inhibition of CSF-1R Supports T-Cell Mediated Melanoma Therapy
por: Sluijter, Marjolein, et al.
Publicado: (2014)

CD47/SIRPα axis: bridging innate and adaptive immunity
por: van Duijn, Anneloes, et al.
Publicado: (2022)

The nonpolymorphic MHC Qa-1(b) mediates CD8(+) T cell surveillance of antigen-processing defects
por: Oliveira, Cláudia C., et al.
Publicado: (2010)

The nonpolymorphic MHC Qa-1(b) mediates CD8(+) T cell surveillance of antigen-processing defects
por: Oliveira, Cláudia C., et al.
Publicado: (2010)

Escape from IFN-γ-dependent immunosurveillance in tumorigenesis
por: Lin, Chiou-Feng, et al.
Publicado: (2017)

Future Challenges in Cancer Resistance to Immunotherapy
por: van Elsas, Marit J., et al.
Publicado: (2020)

SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing
por: Mezzadra, Riccardo, et al.
Publicado: (2019)

Blockade Effects of Anti-Interferon- (IFN-) γ Autoantibodies on IFN-γ-Regulated Antimicrobial Immunity
por: Krisnawati, Dyah Ika, et al.
Publicado: (2019)

Regulatory T Cell Depletion Using a CRISPR Fc-Optimized CD25 Antibody
por: van Elsas, Marit J., et al.
Publicado: (2022)

PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy
por: Kleinovink, Jan Willem, et al.
Publicado: (2017)

NKG2A is a late immune checkpoint on CD8 T cells and marks repeated stimulation and cell division
por: Borst, Linda, et al.
Publicado: (2021)

The role of IFN-γ-signalling in response to immune checkpoint blockade therapy
por: Wong, Chun Wai, et al.
Publicado: (2023)

A novel category of antigens enabling CTL immunity to tumor escape variants: Cinderella antigens
por: Seidel, Ursula J. E., et al.
Publicado: (2011)

Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy
por: Groeneveldt, Christianne, et al.
Publicado: (2022)

In vivo modelling of cutaneous T-cell lymphoma: The role of SOCS1
por: Luo, Yixin, et al.
Publicado: (2022)

Immune Escape of Tumors in Vivo by Expression of Cellular Flice-Inhibitory Protein
por: Medema, Jan Paul, et al.
Publicado: (1999)

Association of cognitive function with increased risk of cancer death and all-cause mortality: Longitudinal analysis, systematic review, and meta-analysis of prospective observational studies
por: Rostamian, Somayeh, et al.
Publicado: (2022)

The Crosstalk between the EGFR and IFN-γ Pathways and Synergistic Roles in Survival Prediction and Immune Escape in Gliomas
por: Zhou, Xingang, et al.
Publicado: (2023)

The positive prognostic effect of stromal CD8+ tumor-infiltrating T cells is restrained by the expression of HLA-E in non-small cell lung carcinoma
por: Yazdi, Mehrdad Talebian, et al.
Publicado: (2015)

Immune inhibitory function of bovine CTLA-4 and the effects of its blockade in IFN-γ production
por: Watari, Kei, et al.
Publicado: (2019)

Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy
por: van Elsas, Marit J, et al.
Publicado: (2023)

Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model
por: Lau, Sai Ping, et al.
Publicado: (2020)

Monalizumab: inhibiting the novel immune checkpoint NKG2A
por: van Hall, Thorbald, et al.
Publicado: (2019)

Abrogation of IFN-γ Signaling May not Worsen Sensitivity to PD-1/PD-L1 Blockade
por: Vackova, Julie, et al.
Publicado: (2020)

Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma
por: Woods, Katherine, et al.
Publicado: (2016)

Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling
por: Apriamashvili, Georgi, et al.
Publicado: (2022)

IFN-γ Rα Is a Key Determinant of CD8+ T Cell-Mediated Tumor Elimination or Tumor Escape and Relapse in FVB Mouse
por: Kmieciak, Maciej, et al.
Publicado: (2013)

Performance of serum-supplemented and serum-free media in IFNγ Elispot Assays for human T cells
por: Janetzki, Sylvia, et al.
Publicado: (2009)

Pharmacological blockade of cannabinoid receptor 2 signaling does not affect LPS/IFN-γ-induced microglial activation
por: Olabiyi, Bolanle Fatimat, et al.
Publicado: (2023)

Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity
por: Garrido, Greta, et al.
Publicado: (2019)

Serum is not required for ex vivo IFN-γ ELISPOT: a collaborative study of different protocols from the European CIMT Immunoguiding Program
por: Mander, A., et al.
Publicado: (2010)

Elevated serum IFN-γand IFN-γ/IL-6 ratio in Kikuchi-Fujimoto disease
por: He, Tingyan, et al.
Publicado: (2023)

Recent Advances in Lupus B Cell Biology: PI3K, IFNγ, and Chromatin
por: Bacalao, Maria A., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hk6m4plce8dvpv9r1s77msi109