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Combination of CDX2 expression and T stage improves prognostic prediction of colorectal cancer
OBJECTIVE: Prognostic prediction of colorectal cancer (CRC) remains challenging because of its heterogeneity. Aberrant expression of caudal-type homeobox transcription factor 2 (CDX2) is strongly correlated with the prognosis of CRC. METHODS: Tissue samples of patients with CRC who underwent surgery...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567745/ https://www.ncbi.nlm.nih.gov/pubmed/30616445 http://dx.doi.org/10.1177/0300060518819620 |
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author | Xu, Weimin Zhu, Yilian Shen, Wei Ding, Wenjun Wu, Tingyu Guo, Yuegui Chen, Xiaobing Zhou, Mingxia Chen, Yingwei Cui, Long Du, Peng |
author_facet | Xu, Weimin Zhu, Yilian Shen, Wei Ding, Wenjun Wu, Tingyu Guo, Yuegui Chen, Xiaobing Zhou, Mingxia Chen, Yingwei Cui, Long Du, Peng |
author_sort | Xu, Weimin |
collection | PubMed |
description | OBJECTIVE: Prognostic prediction of colorectal cancer (CRC) remains challenging because of its heterogeneity. Aberrant expression of caudal-type homeobox transcription factor 2 (CDX2) is strongly correlated with the prognosis of CRC. METHODS: Tissue samples of patients with CRC who underwent surgery in Xinhua Hospital (Shanghai, China) from January 2010 to January 2013 were collected. CDX2 expression was semiquantitatively evaluated via immunohistochemistry. RESULTS: In total, 138 patients were enrolled in this study from a prospectively maintained institutional cancer database. The median follow-up duration was 57.5 months (interquartile range, 17.0–71.0 months). In the Cox proportional hazards model, low CDX2 expression combined with stage T4 CRC was significantly the worst prognostic factor for disease-free survival (hazard ratio = 7.020, 95% confidence interval = 3.922–12.564) and overall survival (hazard ratio = 5.176, 95% CI = 3.237–10.091). In the Kaplan–Meier survival analysis, patients with low CDX2 expression and stage T4 CRC showed significantly worse disease-free survival and overall survival than those with low CDX2 expression alone. CONCLUSION: CDX2 expression combined with the T stage was more accurate for predicting the prognosis of CRC. Determining the prognosis of CRC using more than one variable is valuable in developing appropriate treatment and follow-up strategies. |
format | Online Article Text |
id | pubmed-6567745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-65677452019-06-20 Combination of CDX2 expression and T stage improves prognostic prediction of colorectal cancer Xu, Weimin Zhu, Yilian Shen, Wei Ding, Wenjun Wu, Tingyu Guo, Yuegui Chen, Xiaobing Zhou, Mingxia Chen, Yingwei Cui, Long Du, Peng J Int Med Res Clinical Research Reports OBJECTIVE: Prognostic prediction of colorectal cancer (CRC) remains challenging because of its heterogeneity. Aberrant expression of caudal-type homeobox transcription factor 2 (CDX2) is strongly correlated with the prognosis of CRC. METHODS: Tissue samples of patients with CRC who underwent surgery in Xinhua Hospital (Shanghai, China) from January 2010 to January 2013 were collected. CDX2 expression was semiquantitatively evaluated via immunohistochemistry. RESULTS: In total, 138 patients were enrolled in this study from a prospectively maintained institutional cancer database. The median follow-up duration was 57.5 months (interquartile range, 17.0–71.0 months). In the Cox proportional hazards model, low CDX2 expression combined with stage T4 CRC was significantly the worst prognostic factor for disease-free survival (hazard ratio = 7.020, 95% confidence interval = 3.922–12.564) and overall survival (hazard ratio = 5.176, 95% CI = 3.237–10.091). In the Kaplan–Meier survival analysis, patients with low CDX2 expression and stage T4 CRC showed significantly worse disease-free survival and overall survival than those with low CDX2 expression alone. CONCLUSION: CDX2 expression combined with the T stage was more accurate for predicting the prognosis of CRC. Determining the prognosis of CRC using more than one variable is valuable in developing appropriate treatment and follow-up strategies. SAGE Publications 2019-01-07 2019-05 /pmc/articles/PMC6567745/ /pubmed/30616445 http://dx.doi.org/10.1177/0300060518819620 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Clinical Research Reports Xu, Weimin Zhu, Yilian Shen, Wei Ding, Wenjun Wu, Tingyu Guo, Yuegui Chen, Xiaobing Zhou, Mingxia Chen, Yingwei Cui, Long Du, Peng Combination of CDX2 expression and T stage improves prognostic prediction of colorectal cancer |
title | Combination of CDX2 expression and T stage improves prognostic prediction of colorectal cancer |
title_full | Combination of CDX2 expression and T stage improves prognostic prediction of colorectal cancer |
title_fullStr | Combination of CDX2 expression and T stage improves prognostic prediction of colorectal cancer |
title_full_unstemmed | Combination of CDX2 expression and T stage improves prognostic prediction of colorectal cancer |
title_short | Combination of CDX2 expression and T stage improves prognostic prediction of colorectal cancer |
title_sort | combination of cdx2 expression and t stage improves prognostic prediction of colorectal cancer |
topic | Clinical Research Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567745/ https://www.ncbi.nlm.nih.gov/pubmed/30616445 http://dx.doi.org/10.1177/0300060518819620 |
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