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Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers

Hydrogels incorporated with hydrophobic motifs have received considerable attention to recapitulate the cellular microenvironments, specifically for the bio-mineralization of a 3D matrix. Introduction of hydrophobic molecules into a hydrogel often results in irregular arrangement of the motifs, and...

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Autores principales: Kim, Hee-Jin, Cho, Sungwoo, Oh, Seung Joo, Shin, Sung Gyu, Ryu, Hee Wook, Jeong, Jae Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567794/
https://www.ncbi.nlm.nih.gov/pubmed/31109125
http://dx.doi.org/10.3390/ma12101635
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author Kim, Hee-Jin
Cho, Sungwoo
Oh, Seung Joo
Shin, Sung Gyu
Ryu, Hee Wook
Jeong, Jae Hyun
author_facet Kim, Hee-Jin
Cho, Sungwoo
Oh, Seung Joo
Shin, Sung Gyu
Ryu, Hee Wook
Jeong, Jae Hyun
author_sort Kim, Hee-Jin
collection PubMed
description Hydrogels incorporated with hydrophobic motifs have received considerable attention to recapitulate the cellular microenvironments, specifically for the bio-mineralization of a 3D matrix. Introduction of hydrophobic molecules into a hydrogel often results in irregular arrangement of the motifs, and further phase separation of hydrophobic domains, but limited efforts have been made to resolve this challenge in developing the hydrophobically-modified hydrogel. Therefore, this study presents an advanced integrative strategy to incorporate hydrophobic domains regularly in a hydrogel using self-assembled domains formed with polymer cross-linkers, building blocks of a hydrogel. Self-assemblies formed by polymer cross-linkers were examined as micro-domains to incorporate hydrophobic motifs in a hydrogel. The self-assembled structures in a pre-gelled solution were confirmed with the fluorescence analysis and the hydrophobicity of a hydrogel could be tuned by incorporating the hydrophobic chains in a controlled manner. Overall, the results of this study would greatly serve to tuning performance of a wide array of hydrophobically-modified hydrogels in drug delivery, cell therapies and tissue engineering.
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spelling pubmed-65677942019-06-17 Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers Kim, Hee-Jin Cho, Sungwoo Oh, Seung Joo Shin, Sung Gyu Ryu, Hee Wook Jeong, Jae Hyun Materials (Basel) Article Hydrogels incorporated with hydrophobic motifs have received considerable attention to recapitulate the cellular microenvironments, specifically for the bio-mineralization of a 3D matrix. Introduction of hydrophobic molecules into a hydrogel often results in irregular arrangement of the motifs, and further phase separation of hydrophobic domains, but limited efforts have been made to resolve this challenge in developing the hydrophobically-modified hydrogel. Therefore, this study presents an advanced integrative strategy to incorporate hydrophobic domains regularly in a hydrogel using self-assembled domains formed with polymer cross-linkers, building blocks of a hydrogel. Self-assemblies formed by polymer cross-linkers were examined as micro-domains to incorporate hydrophobic motifs in a hydrogel. The self-assembled structures in a pre-gelled solution were confirmed with the fluorescence analysis and the hydrophobicity of a hydrogel could be tuned by incorporating the hydrophobic chains in a controlled manner. Overall, the results of this study would greatly serve to tuning performance of a wide array of hydrophobically-modified hydrogels in drug delivery, cell therapies and tissue engineering. MDPI 2019-05-19 /pmc/articles/PMC6567794/ /pubmed/31109125 http://dx.doi.org/10.3390/ma12101635 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Hee-Jin
Cho, Sungwoo
Oh, Seung Joo
Shin, Sung Gyu
Ryu, Hee Wook
Jeong, Jae Hyun
Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers
title Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers
title_full Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers
title_fullStr Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers
title_full_unstemmed Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers
title_short Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers
title_sort tuning the hydrophobicity of a hydrogel using self-assembled domains of polymer cross-linkers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567794/
https://www.ncbi.nlm.nih.gov/pubmed/31109125
http://dx.doi.org/10.3390/ma12101635
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