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HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma

Holliday Junction Recognition Protein (HJURP) is involved in various cancers including hepatocellular carcinoma (HCC). Current studies have showed that HJURP is correlated with HCC proliferation. However, the role of HJURP in HCC Epithelial-to-Mesenchymal Transition remains unclear. In this study, w...

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Autores principales: Chen, Tianchi, Zhou, Lingfeng, Zhou, Yuan, Zhou, Wuhua, Huang, Hechen, Yin, Shengyong, Xie, Haiyang, Zhou, Lin, Zheng, Shusen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567799/
https://www.ncbi.nlm.nih.gov/pubmed/31223275
http://dx.doi.org/10.7150/ijbs.30904
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author Chen, Tianchi
Zhou, Lingfeng
Zhou, Yuan
Zhou, Wuhua
Huang, Hechen
Yin, Shengyong
Xie, Haiyang
Zhou, Lin
Zheng, Shusen
author_facet Chen, Tianchi
Zhou, Lingfeng
Zhou, Yuan
Zhou, Wuhua
Huang, Hechen
Yin, Shengyong
Xie, Haiyang
Zhou, Lin
Zheng, Shusen
author_sort Chen, Tianchi
collection PubMed
description Holliday Junction Recognition Protein (HJURP) is involved in various cancers including hepatocellular carcinoma (HCC). Current studies have showed that HJURP is correlated with HCC proliferation. However, the role of HJURP in HCC Epithelial-to-Mesenchymal Transition remains unclear. In this study, we found that HJURP knockdown significantly reduced the migration and invasion abilities of HCC cells both in vivo and in vitro by interacting with Sphingosine kinase1 (SPHK1). Conversely, HJURP overexpression enhanced these biological abilities. Moreover, high HJURP expression is related to poor prognosis of HCC patients. In conclusion, HJURP plays an important role in tumor metastasis by upregulating SPHK1. And high HJURP expression may predict a lower disease-free survival rate and higher possibility of microvascular invasion in HCC patients.
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spelling pubmed-65677992019-06-20 HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma Chen, Tianchi Zhou, Lingfeng Zhou, Yuan Zhou, Wuhua Huang, Hechen Yin, Shengyong Xie, Haiyang Zhou, Lin Zheng, Shusen Int J Biol Sci Research Paper Holliday Junction Recognition Protein (HJURP) is involved in various cancers including hepatocellular carcinoma (HCC). Current studies have showed that HJURP is correlated with HCC proliferation. However, the role of HJURP in HCC Epithelial-to-Mesenchymal Transition remains unclear. In this study, we found that HJURP knockdown significantly reduced the migration and invasion abilities of HCC cells both in vivo and in vitro by interacting with Sphingosine kinase1 (SPHK1). Conversely, HJURP overexpression enhanced these biological abilities. Moreover, high HJURP expression is related to poor prognosis of HCC patients. In conclusion, HJURP plays an important role in tumor metastasis by upregulating SPHK1. And high HJURP expression may predict a lower disease-free survival rate and higher possibility of microvascular invasion in HCC patients. Ivyspring International Publisher 2019-05-07 /pmc/articles/PMC6567799/ /pubmed/31223275 http://dx.doi.org/10.7150/ijbs.30904 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Chen, Tianchi
Zhou, Lingfeng
Zhou, Yuan
Zhou, Wuhua
Huang, Hechen
Yin, Shengyong
Xie, Haiyang
Zhou, Lin
Zheng, Shusen
HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma
title HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma
title_full HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma
title_fullStr HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma
title_full_unstemmed HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma
title_short HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma
title_sort hjurp promotes epithelial-to-mesenchymal transition via upregulating sphk1 in hepatocellular carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567799/
https://www.ncbi.nlm.nih.gov/pubmed/31223275
http://dx.doi.org/10.7150/ijbs.30904
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