HER2-Specific Targeted Toxin DARPin-LoPE: Immunogenicity and Antitumor Effect on Intraperitoneal Ovarian Cancer Xenograft Model

High immunogenicity and systemic toxicity are the main obstacles limiting the clinical use of the therapeutic agents based on Pseudomonas aeruginosa exotoxin A. In this work, we studied the immunogenicity, general toxicity and antitumor effect of the targeted toxin DARPin-LoPE composed of HER2-speci...

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Detalles Bibliográficos
Autores principales: Sokolova, Evgeniya A., Shilova, Olga N., Kiseleva, Daria V., Schulga, Alexey A., Balalaeva, Irina V., Deyev, Sergey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567818/
https://www.ncbi.nlm.nih.gov/pubmed/31096563
http://dx.doi.org/10.3390/ijms20102399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567818/
https://www.ncbi.nlm.nih.gov/pubmed/31096563
http://dx.doi.org/10.3390/ijms20102399

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