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Trained Innate Immunity Not Always Amicable

The concept of “trained innate immunity” is understood as the ability of innate immune cells to remember invading agents and to respond nonspecifically to reinfection with increased strength. Trained immunity is orchestrated by epigenetic modifications leading to changes in gene expression and cell...

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Detalles Bibliográficos
Autores principales: Włodarczyk, Marcin, Druszczyńska, Magdalena, Fol, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567865/
https://www.ncbi.nlm.nih.gov/pubmed/31137759
http://dx.doi.org/10.3390/ijms20102565
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author Włodarczyk, Marcin
Druszczyńska, Magdalena
Fol, Marek
author_facet Włodarczyk, Marcin
Druszczyńska, Magdalena
Fol, Marek
author_sort Włodarczyk, Marcin
collection PubMed
description The concept of “trained innate immunity” is understood as the ability of innate immune cells to remember invading agents and to respond nonspecifically to reinfection with increased strength. Trained immunity is orchestrated by epigenetic modifications leading to changes in gene expression and cell physiology. Although this phenomenon was originally seen mainly as a beneficial effect, since it confers broad immunological protection, enhanced immune response of reprogrammed innate immune cells might result in the development or persistence of chronic metabolic, autoimmune or neuroinfalmmatory disorders. This paper overviews several examples where the induction of trained immunity may be essential in the development of diseases characterized by flawed innate immune response.
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spelling pubmed-65678652019-06-17 Trained Innate Immunity Not Always Amicable Włodarczyk, Marcin Druszczyńska, Magdalena Fol, Marek Int J Mol Sci Review The concept of “trained innate immunity” is understood as the ability of innate immune cells to remember invading agents and to respond nonspecifically to reinfection with increased strength. Trained immunity is orchestrated by epigenetic modifications leading to changes in gene expression and cell physiology. Although this phenomenon was originally seen mainly as a beneficial effect, since it confers broad immunological protection, enhanced immune response of reprogrammed innate immune cells might result in the development or persistence of chronic metabolic, autoimmune or neuroinfalmmatory disorders. This paper overviews several examples where the induction of trained immunity may be essential in the development of diseases characterized by flawed innate immune response. MDPI 2019-05-24 /pmc/articles/PMC6567865/ /pubmed/31137759 http://dx.doi.org/10.3390/ijms20102565 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Włodarczyk, Marcin
Druszczyńska, Magdalena
Fol, Marek
Trained Innate Immunity Not Always Amicable
title Trained Innate Immunity Not Always Amicable
title_full Trained Innate Immunity Not Always Amicable
title_fullStr Trained Innate Immunity Not Always Amicable
title_full_unstemmed Trained Innate Immunity Not Always Amicable
title_short Trained Innate Immunity Not Always Amicable
title_sort trained innate immunity not always amicable
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567865/
https://www.ncbi.nlm.nih.gov/pubmed/31137759
http://dx.doi.org/10.3390/ijms20102565
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