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Trained Innate Immunity Not Always Amicable
The concept of “trained innate immunity” is understood as the ability of innate immune cells to remember invading agents and to respond nonspecifically to reinfection with increased strength. Trained immunity is orchestrated by epigenetic modifications leading to changes in gene expression and cell...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567865/ https://www.ncbi.nlm.nih.gov/pubmed/31137759 http://dx.doi.org/10.3390/ijms20102565 |
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author | Włodarczyk, Marcin Druszczyńska, Magdalena Fol, Marek |
author_facet | Włodarczyk, Marcin Druszczyńska, Magdalena Fol, Marek |
author_sort | Włodarczyk, Marcin |
collection | PubMed |
description | The concept of “trained innate immunity” is understood as the ability of innate immune cells to remember invading agents and to respond nonspecifically to reinfection with increased strength. Trained immunity is orchestrated by epigenetic modifications leading to changes in gene expression and cell physiology. Although this phenomenon was originally seen mainly as a beneficial effect, since it confers broad immunological protection, enhanced immune response of reprogrammed innate immune cells might result in the development or persistence of chronic metabolic, autoimmune or neuroinfalmmatory disorders. This paper overviews several examples where the induction of trained immunity may be essential in the development of diseases characterized by flawed innate immune response. |
format | Online Article Text |
id | pubmed-6567865 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65678652019-06-17 Trained Innate Immunity Not Always Amicable Włodarczyk, Marcin Druszczyńska, Magdalena Fol, Marek Int J Mol Sci Review The concept of “trained innate immunity” is understood as the ability of innate immune cells to remember invading agents and to respond nonspecifically to reinfection with increased strength. Trained immunity is orchestrated by epigenetic modifications leading to changes in gene expression and cell physiology. Although this phenomenon was originally seen mainly as a beneficial effect, since it confers broad immunological protection, enhanced immune response of reprogrammed innate immune cells might result in the development or persistence of chronic metabolic, autoimmune or neuroinfalmmatory disorders. This paper overviews several examples where the induction of trained immunity may be essential in the development of diseases characterized by flawed innate immune response. MDPI 2019-05-24 /pmc/articles/PMC6567865/ /pubmed/31137759 http://dx.doi.org/10.3390/ijms20102565 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Włodarczyk, Marcin Druszczyńska, Magdalena Fol, Marek Trained Innate Immunity Not Always Amicable |
title | Trained Innate Immunity Not Always Amicable |
title_full | Trained Innate Immunity Not Always Amicable |
title_fullStr | Trained Innate Immunity Not Always Amicable |
title_full_unstemmed | Trained Innate Immunity Not Always Amicable |
title_short | Trained Innate Immunity Not Always Amicable |
title_sort | trained innate immunity not always amicable |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567865/ https://www.ncbi.nlm.nih.gov/pubmed/31137759 http://dx.doi.org/10.3390/ijms20102565 |
work_keys_str_mv | AT włodarczykmarcin trainedinnateimmunitynotalwaysamicable AT druszczynskamagdalena trainedinnateimmunitynotalwaysamicable AT folmarek trainedinnateimmunitynotalwaysamicable |