Cargando…
AIE-based theranostic systems for detection and killing of pathogens
Pathogenic bacteria, fungi and viruses pose serious threats to the human health under appropriate conditions. There are many rapid and sensitive approaches have been developed for identification and quantification of specific pathogens, but many challenges still exist. Culture/colony counting and po...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567968/ https://www.ncbi.nlm.nih.gov/pubmed/31244951 http://dx.doi.org/10.7150/thno.31844 |
_version_ | 1783427191316414464 |
---|---|
author | He, Xuewen Xiong, Ling-Hong Zhao, Zheng Wang, Zaiyu Luo, Liang Lam, Jacky Wing Yip Kwok, Ryan Tsz Kin Tang, Ben Zhong |
author_facet | He, Xuewen Xiong, Ling-Hong Zhao, Zheng Wang, Zaiyu Luo, Liang Lam, Jacky Wing Yip Kwok, Ryan Tsz Kin Tang, Ben Zhong |
author_sort | He, Xuewen |
collection | PubMed |
description | Pathogenic bacteria, fungi and viruses pose serious threats to the human health under appropriate conditions. There are many rapid and sensitive approaches have been developed for identification and quantification of specific pathogens, but many challenges still exist. Culture/colony counting and polymerase chain reaction are the classical methods used for pathogen detection, but their operations are time-consuming and laborious. On the other hand, the emergence and rapid spread of multidrug-resistant pathogens is another global threat. It is thus of utmost urgency to develop new therapeutic agents or strategies. Luminogens with aggregation-induced emission (AIEgens) and their derived supramolecular systems with unique optical properties have been developed as fluorescent probes for turn-on sensing of pathogens with high sensitivity and specificity. In addition, AIE-based supramolecular nanostructures exhibit excellent photodynamic inactivation (PDI) activity in aggregate, offering great potential for not only light-up diagnosis of pathogen, but also image-guided PDI therapy for pathogenic infection. |
format | Online Article Text |
id | pubmed-6567968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-65679682019-06-26 AIE-based theranostic systems for detection and killing of pathogens He, Xuewen Xiong, Ling-Hong Zhao, Zheng Wang, Zaiyu Luo, Liang Lam, Jacky Wing Yip Kwok, Ryan Tsz Kin Tang, Ben Zhong Theranostics Review Pathogenic bacteria, fungi and viruses pose serious threats to the human health under appropriate conditions. There are many rapid and sensitive approaches have been developed for identification and quantification of specific pathogens, but many challenges still exist. Culture/colony counting and polymerase chain reaction are the classical methods used for pathogen detection, but their operations are time-consuming and laborious. On the other hand, the emergence and rapid spread of multidrug-resistant pathogens is another global threat. It is thus of utmost urgency to develop new therapeutic agents or strategies. Luminogens with aggregation-induced emission (AIEgens) and their derived supramolecular systems with unique optical properties have been developed as fluorescent probes for turn-on sensing of pathogens with high sensitivity and specificity. In addition, AIE-based supramolecular nanostructures exhibit excellent photodynamic inactivation (PDI) activity in aggregate, offering great potential for not only light-up diagnosis of pathogen, but also image-guided PDI therapy for pathogenic infection. Ivyspring International Publisher 2019-05-18 /pmc/articles/PMC6567968/ /pubmed/31244951 http://dx.doi.org/10.7150/thno.31844 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review He, Xuewen Xiong, Ling-Hong Zhao, Zheng Wang, Zaiyu Luo, Liang Lam, Jacky Wing Yip Kwok, Ryan Tsz Kin Tang, Ben Zhong AIE-based theranostic systems for detection and killing of pathogens |
title | AIE-based theranostic systems for detection and killing of pathogens |
title_full | AIE-based theranostic systems for detection and killing of pathogens |
title_fullStr | AIE-based theranostic systems for detection and killing of pathogens |
title_full_unstemmed | AIE-based theranostic systems for detection and killing of pathogens |
title_short | AIE-based theranostic systems for detection and killing of pathogens |
title_sort | aie-based theranostic systems for detection and killing of pathogens |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567968/ https://www.ncbi.nlm.nih.gov/pubmed/31244951 http://dx.doi.org/10.7150/thno.31844 |
work_keys_str_mv | AT hexuewen aiebasedtheranosticsystemsfordetectionandkillingofpathogens AT xionglinghong aiebasedtheranosticsystemsfordetectionandkillingofpathogens AT zhaozheng aiebasedtheranosticsystemsfordetectionandkillingofpathogens AT wangzaiyu aiebasedtheranosticsystemsfordetectionandkillingofpathogens AT luoliang aiebasedtheranosticsystemsfordetectionandkillingofpathogens AT lamjackywingyip aiebasedtheranosticsystemsfordetectionandkillingofpathogens AT kwokryantszkin aiebasedtheranosticsystemsfordetectionandkillingofpathogens AT tangbenzhong aiebasedtheranosticsystemsfordetectionandkillingofpathogens |