Bioengineering of Metal-organic Frameworks for Nanomedicine

Controlled structure, tunable porosity, and readily chemical functionalizability make metal-organic frameworks (MOFs) a powerful biomedical tool. Nanoscale MOF particles have been increasingly studied as drug carriers, bioimaging agents, and therapeutic agents due to their excellent physiochemical p...

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Detalles Bibliográficos
Autores principales: Liu, Yuan, Zhao, Yanli, Chen, Xiaoyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567971/
https://www.ncbi.nlm.nih.gov/pubmed/31244945
http://dx.doi.org/10.7150/thno.31918
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author Liu, Yuan
Zhao, Yanli
Chen, Xiaoyuan
author_facet Liu, Yuan
Zhao, Yanli
Chen, Xiaoyuan
author_sort Liu, Yuan
collection PubMed
description Controlled structure, tunable porosity, and readily chemical functionalizability make metal-organic frameworks (MOFs) a powerful biomedical tool. Nanoscale MOF particles have been increasingly studied as drug carriers, bioimaging agents, and therapeutic agents due to their excellent physiochemical properties. In this review, we start with MOF as a nanocarrier for drug delivery, covering therapeutic MOF agents followed by a comprehensive discussion of surface bioengineering of MOF for improved biostability, biocompatibility, and targeted delivery. Finally, we detail the challenges and prospects of the future of MOF research for biomedical applications.
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spelling pubmed-65679712019-06-26 Bioengineering of Metal-organic Frameworks for Nanomedicine Liu, Yuan Zhao, Yanli Chen, Xiaoyuan Theranostics Review Controlled structure, tunable porosity, and readily chemical functionalizability make metal-organic frameworks (MOFs) a powerful biomedical tool. Nanoscale MOF particles have been increasingly studied as drug carriers, bioimaging agents, and therapeutic agents due to their excellent physiochemical properties. In this review, we start with MOF as a nanocarrier for drug delivery, covering therapeutic MOF agents followed by a comprehensive discussion of surface bioengineering of MOF for improved biostability, biocompatibility, and targeted delivery. Finally, we detail the challenges and prospects of the future of MOF research for biomedical applications. Ivyspring International Publisher 2019-05-18 /pmc/articles/PMC6567971/ /pubmed/31244945 http://dx.doi.org/10.7150/thno.31918 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Liu, Yuan
Zhao, Yanli
Chen, Xiaoyuan
Bioengineering of Metal-organic Frameworks for Nanomedicine
title Bioengineering of Metal-organic Frameworks for Nanomedicine
title_full Bioengineering of Metal-organic Frameworks for Nanomedicine
title_fullStr Bioengineering of Metal-organic Frameworks for Nanomedicine
title_full_unstemmed Bioengineering of Metal-organic Frameworks for Nanomedicine
title_short Bioengineering of Metal-organic Frameworks for Nanomedicine
title_sort bioengineering of metal-organic frameworks for nanomedicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567971/
https://www.ncbi.nlm.nih.gov/pubmed/31244945
http://dx.doi.org/10.7150/thno.31918
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