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Complement Nomenclature—Deconvoluted
In 2014, specific recommendations for complement nomenclature were presented by the complement field. There remained some unresolved designations and new areas of ambiguity, and here we propose solutions to resolve these remaining issues. To enable rapid understanding of the intricate complement sys...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568193/ https://www.ncbi.nlm.nih.gov/pubmed/31231398 http://dx.doi.org/10.3389/fimmu.2019.01308 |
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author | Bohlson, Suzanne S. Garred, Peter Kemper, Claudia Tenner, Andrea J. |
author_facet | Bohlson, Suzanne S. Garred, Peter Kemper, Claudia Tenner, Andrea J. |
author_sort | Bohlson, Suzanne S. |
collection | PubMed |
description | In 2014, specific recommendations for complement nomenclature were presented by the complement field. There remained some unresolved designations and new areas of ambiguity, and here we propose solutions to resolve these remaining issues. To enable rapid understanding of the intricate complement system and facilitate therapeutic development and application, a uniform nomenclature for cleavage fragments, pattern recognition molecules (PRMs) and enzymes of the lectin pathway and regulatory proteins of the complement system are proposed, and a standardization of language to designate different activation states of complement components is recommended. |
format | Online Article Text |
id | pubmed-6568193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65681932019-06-21 Complement Nomenclature—Deconvoluted Bohlson, Suzanne S. Garred, Peter Kemper, Claudia Tenner, Andrea J. Front Immunol Immunology In 2014, specific recommendations for complement nomenclature were presented by the complement field. There remained some unresolved designations and new areas of ambiguity, and here we propose solutions to resolve these remaining issues. To enable rapid understanding of the intricate complement system and facilitate therapeutic development and application, a uniform nomenclature for cleavage fragments, pattern recognition molecules (PRMs) and enzymes of the lectin pathway and regulatory proteins of the complement system are proposed, and a standardization of language to designate different activation states of complement components is recommended. Frontiers Media S.A. 2019-06-07 /pmc/articles/PMC6568193/ /pubmed/31231398 http://dx.doi.org/10.3389/fimmu.2019.01308 Text en Copyright © 2019 Bohlson, Garred, Kemper and Tenner. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Bohlson, Suzanne S. Garred, Peter Kemper, Claudia Tenner, Andrea J. Complement Nomenclature—Deconvoluted |
title | Complement Nomenclature—Deconvoluted |
title_full | Complement Nomenclature—Deconvoluted |
title_fullStr | Complement Nomenclature—Deconvoluted |
title_full_unstemmed | Complement Nomenclature—Deconvoluted |
title_short | Complement Nomenclature—Deconvoluted |
title_sort | complement nomenclature—deconvoluted |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568193/ https://www.ncbi.nlm.nih.gov/pubmed/31231398 http://dx.doi.org/10.3389/fimmu.2019.01308 |
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