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Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment
Due to their crucial role in cell metabolism and homeostasis, alterations in mitochondrial biology and function have been related to the progression of diverse diseases including cancer. One of the consequences associated to mitochondrial dysfunction is the production of reactive oxygen species (ROS...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568240/ https://www.ncbi.nlm.nih.gov/pubmed/31231612 http://dx.doi.org/10.3389/fonc.2019.00480 |
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author | Sarmiento-Salinas, Fabiola Lilí Delgado-Magallón, Alam Montes-Alvarado, José Benito Ramírez-Ramírez, Dalia Flores-Alonso, Juan Carlos Cortés-Hernández, Paulina Reyes-Leyva, Julio Herrera-Camacho, Irma Anaya-Ruiz, Maricruz Pelayo, Rosana Millán-Pérez-Peña, Lourdes Maycotte, Paola |
author_facet | Sarmiento-Salinas, Fabiola Lilí Delgado-Magallón, Alam Montes-Alvarado, José Benito Ramírez-Ramírez, Dalia Flores-Alonso, Juan Carlos Cortés-Hernández, Paulina Reyes-Leyva, Julio Herrera-Camacho, Irma Anaya-Ruiz, Maricruz Pelayo, Rosana Millán-Pérez-Peña, Lourdes Maycotte, Paola |
author_sort | Sarmiento-Salinas, Fabiola Lilí |
collection | PubMed |
description | Due to their crucial role in cell metabolism and homeostasis, alterations in mitochondrial biology and function have been related to the progression of diverse diseases including cancer. One of the consequences associated to mitochondrial dysfunction is the production of reactive oxygen species (ROS). ROS are known to have a controversial role during cancer initiation and progression and although several studies have tried to manipulate intracellular ROS levels using antioxidants or pro-oxidation conditions, it is not yet clear how to target oxidation for cancer therapy. In this study, we found differences in mitochondrial morphology in breast cancer cells when compared to a non-tumorigenic cell line and differences in mitochondrial function among breast cancer subtypes when exploring gene-expression data from the TCGA tumor dataset. Interestingly, we found increased ROS levels in triple negative breast cancer (TNBC) cell lines and a dependency on ROS for survival since antioxidant treatment induced cell death in TNBC cells but not in an estrogen receptor positive (ER+) cell line. Moreover, we identified the mitochondria as the main source of ROS in TNBC cell lines. Our results indicate a potential use for ROS as a target for therapy in the TNBC subtype which currently has the worst prognosis among all breast cancers and remains as the only breast cancer subtype which lacks a targeted therapy. |
format | Online Article Text |
id | pubmed-6568240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65682402019-06-21 Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment Sarmiento-Salinas, Fabiola Lilí Delgado-Magallón, Alam Montes-Alvarado, José Benito Ramírez-Ramírez, Dalia Flores-Alonso, Juan Carlos Cortés-Hernández, Paulina Reyes-Leyva, Julio Herrera-Camacho, Irma Anaya-Ruiz, Maricruz Pelayo, Rosana Millán-Pérez-Peña, Lourdes Maycotte, Paola Front Oncol Oncology Due to their crucial role in cell metabolism and homeostasis, alterations in mitochondrial biology and function have been related to the progression of diverse diseases including cancer. One of the consequences associated to mitochondrial dysfunction is the production of reactive oxygen species (ROS). ROS are known to have a controversial role during cancer initiation and progression and although several studies have tried to manipulate intracellular ROS levels using antioxidants or pro-oxidation conditions, it is not yet clear how to target oxidation for cancer therapy. In this study, we found differences in mitochondrial morphology in breast cancer cells when compared to a non-tumorigenic cell line and differences in mitochondrial function among breast cancer subtypes when exploring gene-expression data from the TCGA tumor dataset. Interestingly, we found increased ROS levels in triple negative breast cancer (TNBC) cell lines and a dependency on ROS for survival since antioxidant treatment induced cell death in TNBC cells but not in an estrogen receptor positive (ER+) cell line. Moreover, we identified the mitochondria as the main source of ROS in TNBC cell lines. Our results indicate a potential use for ROS as a target for therapy in the TNBC subtype which currently has the worst prognosis among all breast cancers and remains as the only breast cancer subtype which lacks a targeted therapy. Frontiers Media S.A. 2019-06-07 /pmc/articles/PMC6568240/ /pubmed/31231612 http://dx.doi.org/10.3389/fonc.2019.00480 Text en Copyright © 2019 Sarmiento-Salinas, Delgado-Magallón, Montes-Alvarado, Ramírez-Ramírez, Flores-Alonso, Cortés-Hernández, Reyes-Leyva, Herrera-Camacho, Anaya-Ruiz, Pelayo, Millán-Pérez-Peña and Maycotte. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Sarmiento-Salinas, Fabiola Lilí Delgado-Magallón, Alam Montes-Alvarado, José Benito Ramírez-Ramírez, Dalia Flores-Alonso, Juan Carlos Cortés-Hernández, Paulina Reyes-Leyva, Julio Herrera-Camacho, Irma Anaya-Ruiz, Maricruz Pelayo, Rosana Millán-Pérez-Peña, Lourdes Maycotte, Paola Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment |
title | Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment |
title_full | Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment |
title_fullStr | Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment |
title_full_unstemmed | Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment |
title_short | Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment |
title_sort | breast cancer subtypes present a differential production of reactive oxygen species (ros) and susceptibility to antioxidant treatment |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568240/ https://www.ncbi.nlm.nih.gov/pubmed/31231612 http://dx.doi.org/10.3389/fonc.2019.00480 |
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