Systematic analysis of Type I‐E Escherichia coli CRISPR‐Cas PAM sequences ability to promote interference and primed adaptation

CRISPR interference occurs when a protospacer recognized by the CRISPR RNA is destroyed by Cas effectors. In Type I CRISPR‐Cas systems, protospacer recognition can lead to «primed adaptation» – acquisition of new spacers from in cis located sequences. Type I CRISPR‐Cas systems require the presence o...

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Detalles Bibliográficos
Autores principales: Musharova, Olga, Sitnik, Vasily, Vlot, Marnix, Savitskaya, Ekaterina, Datsenko, Kirill A., Krivoy, Andrey, Fedorov, Ivan, Semenova, Ekaterina, Brouns, Stan J. J., Severinov, Konstantin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568314/
https://www.ncbi.nlm.nih.gov/pubmed/30875129
http://dx.doi.org/10.1111/mmi.14237

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