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Recurrent maternal CMV infection associated with symptomatic congenital infection: results from a questionnaire study in Portugal
OBJECTIVE: Human cytomegalovirus (CMV) is the most widespread agent of congenital infection in humans and is still a challenging issue. Despite lower rates of vertical transmission being associated with recurrent infection when compared with primary infection, the first still represents the majority...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570486/ https://www.ncbi.nlm.nih.gov/pubmed/31263791 http://dx.doi.org/10.1136/bmjpo-2019-000455 |
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author | Paixão, Paulo Brito, Maria João Virella, Daniel Neto, Maria Teresa |
author_facet | Paixão, Paulo Brito, Maria João Virella, Daniel Neto, Maria Teresa |
author_sort | Paixão, Paulo |
collection | PubMed |
description | OBJECTIVE: Human cytomegalovirus (CMV) is the most widespread agent of congenital infection in humans and is still a challenging issue. Despite lower rates of vertical transmission being associated with recurrent infection when compared with primary infection, the first still represents the majority of congenital infections worldwide. Based on data from active reporting, we explored the influence of maternal primary/non-primary infection both on the presentation and outcome of congenital CMV infection in early childhood. DESIGN: Infants with positive viruria during the first 3 weeks of life were reported through the Portuguese Paediatric Surveillance Unit. PATIENTS: Infants born between 2006 and 2011 with confirmed congenital CMV infection. METHODS: Maternal infection was considered primary if CMV IgG seroconversion occurred during pregnancy or low avidity IgG was documented; it was considered non-primary if positive IgG was documented before pregnancy or high avidity CMV IgG was present early in pregnancy. Follow-up questionnaires were sent up to 6 years of age. RESULTS: Forty confirmed cases of congenital CMV infection were reported (6.6:10(5) live births, 95% CI 4.81 to 8.92); 22 out of 40 were asymptomatic. The odds for non-primary maternal infection if the offspring was symptomatic at birth were 6.2 (95% CI 1.2 to 32.27). CONCLUSION: The reported number of confirmed cases of congenital CMV infection was much lower than expected. Under-reporting and missed diagnosis were considered possible reasons. Non-primary maternal infections were associated with symptomatic congenital CMV infection in the offspring. Maternal recurrent infections can have a significant impact on the total number of symptomatic infections in Portugal. |
format | Online Article Text |
id | pubmed-6570486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-65704862019-07-01 Recurrent maternal CMV infection associated with symptomatic congenital infection: results from a questionnaire study in Portugal Paixão, Paulo Brito, Maria João Virella, Daniel Neto, Maria Teresa BMJ Paediatr Open Infectious Diseases OBJECTIVE: Human cytomegalovirus (CMV) is the most widespread agent of congenital infection in humans and is still a challenging issue. Despite lower rates of vertical transmission being associated with recurrent infection when compared with primary infection, the first still represents the majority of congenital infections worldwide. Based on data from active reporting, we explored the influence of maternal primary/non-primary infection both on the presentation and outcome of congenital CMV infection in early childhood. DESIGN: Infants with positive viruria during the first 3 weeks of life were reported through the Portuguese Paediatric Surveillance Unit. PATIENTS: Infants born between 2006 and 2011 with confirmed congenital CMV infection. METHODS: Maternal infection was considered primary if CMV IgG seroconversion occurred during pregnancy or low avidity IgG was documented; it was considered non-primary if positive IgG was documented before pregnancy or high avidity CMV IgG was present early in pregnancy. Follow-up questionnaires were sent up to 6 years of age. RESULTS: Forty confirmed cases of congenital CMV infection were reported (6.6:10(5) live births, 95% CI 4.81 to 8.92); 22 out of 40 were asymptomatic. The odds for non-primary maternal infection if the offspring was symptomatic at birth were 6.2 (95% CI 1.2 to 32.27). CONCLUSION: The reported number of confirmed cases of congenital CMV infection was much lower than expected. Under-reporting and missed diagnosis were considered possible reasons. Non-primary maternal infections were associated with symptomatic congenital CMV infection in the offspring. Maternal recurrent infections can have a significant impact on the total number of symptomatic infections in Portugal. BMJ Publishing Group 2019-06-02 /pmc/articles/PMC6570486/ /pubmed/31263791 http://dx.doi.org/10.1136/bmjpo-2019-000455 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Infectious Diseases Paixão, Paulo Brito, Maria João Virella, Daniel Neto, Maria Teresa Recurrent maternal CMV infection associated with symptomatic congenital infection: results from a questionnaire study in Portugal |
title | Recurrent maternal CMV infection associated with symptomatic congenital infection: results from a questionnaire study in Portugal |
title_full | Recurrent maternal CMV infection associated with symptomatic congenital infection: results from a questionnaire study in Portugal |
title_fullStr | Recurrent maternal CMV infection associated with symptomatic congenital infection: results from a questionnaire study in Portugal |
title_full_unstemmed | Recurrent maternal CMV infection associated with symptomatic congenital infection: results from a questionnaire study in Portugal |
title_short | Recurrent maternal CMV infection associated with symptomatic congenital infection: results from a questionnaire study in Portugal |
title_sort | recurrent maternal cmv infection associated with symptomatic congenital infection: results from a questionnaire study in portugal |
topic | Infectious Diseases |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570486/ https://www.ncbi.nlm.nih.gov/pubmed/31263791 http://dx.doi.org/10.1136/bmjpo-2019-000455 |
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